Effect of Bushen Granule on the Expressions of CD28 and CD95 in Chronic Aplastic Anemia Patients

WANG Yunlǜ; HAN Huijie; LIU Min; HU Qi; XIA Lemin; ZHANG Xiaofeng

doi:10.13288/j.11-2166/r.2010.04.013

您当前的位置：

首页 >

文章列表页 >

Effect of Bushen Granule on the Expressions of CD28 and CD95 in Chronic Aplastic Anemia Patients

更新时间：2021-11-17

- Effect of Bushen Granule on the Expressions of CD28 and CD95 in Chronic Aplastic Anemia Patients
- Journal of Traditional Chinese Medicine Vol. 51, Issue 4, Pages: 323-325(2010)
- 作者机构：
  
  上海市中医医院血液科
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2010.04.013
  CLC： R259
- Published：2010
- 稿件说明：
移动端阅览
[1]王运律,韩惠杰,刘敏,胡琦,夏乐敏,张晓峰.补肾颗粒对慢性再生障碍性贫血患者CD28、CD95表达的影响[J].中医杂志,2010,51(04):323-325.

WANG Yunlǜ, HAN Huijie, LIU Min, et al. Effect of Bushen Granule on the Expressions of CD28 and CD95 in Chronic Aplastic Anemia Patients[J]. Journal of Traditional Chinese Medicine2010, 51(4): 323-325.
[1]王运律,韩惠杰,刘敏,胡琦,夏乐敏,张晓峰.补肾颗粒对慢性再生障碍性贫血患者CD28、CD95表达的影响[J].中医杂志,2010,51(04):323-325. DOI： 10.13288/j.11-2166/r.2010.04.013.

WANG Yunlǜ, HAN Huijie, LIU Min, et al. Effect of Bushen Granule on the Expressions of CD28 and CD95 in Chronic Aplastic Anemia Patients[J]. Journal of Traditional Chinese Medicine2010, 51(4): 323-325. DOI： 10.13288/j.11-2166/r.2010.04.013.

摘要

目的探讨补肾颗粒治疗慢性再生障碍性贫血（CAA）的作用机制。方法将CAA患者分为中药组（60例）和环胞菌素A组（CsA组

16例）;中药组以补肾颗粒为主辨证治疗

CsA组以环孢菌素A为主治疗

疗程6个月

另设健康对照组20名

比较健康对照组与CAA各组治疗前后CD3+、CD3+CD28+、CD3+CD95+的表达水平。结果CAA各组治疗前CD3+、CD3+CD28+、CD3+CD95+的表达均较健康对照组高（P<0.05）

以肾阴虚型表达异常更甚。各组治疗后CD28表达下调

CD95表达上调。结论CAA患者T细胞CD28及CD95表达异常;补肾颗粒可能通过调节CD28及CD95水平调控CAA患者T细胞的异常激活和凋亡

从而促进造血功能恢复。

Abstract

Objective To study the mechanism of Bushen Granule （G ranule for rein forcing the kidney） for the treatment of chronic aplastic anemia （CAA）. Methods The CAA patients were divided into the herbal group （60 cases） treated mainly by Bu shen Granule with syndrome differentiation and the Cyclosporin A group （16 cases ） tr eated mainly by Cyclosporin A for 6 months. The healthy control group consisting of 20 healthy subjects was set up. The expressions of CD3 +

CD3+CD28+

and CD3+CD95+ of the healthy control groups were compared with the herbal group and the Cyclosporin A group. Results The expressions of CD3 +

CD3+CD28+

and CD3+CD9 5+ of the CAA groups were higher than those of the healthy control group （P<0.05）

especia lly in those who were of kidney yin deficiency syndrome. In the treated groups

the expression of CD28 was down-regulated while that of CD95+ was up-regula ted. Conclusion B ushen Granule is able to regulate the abnormally activated T cells and their apo ptosis through regulating the expressions of CD28 and CD95

thus the hematopoiet ic function is restored.

关键词

Keywords

references

查看原文

Views

136

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Similarities and Differences between Myofascial Trigger Points and Sinew Knot：from the Perspective of the Channel Sinew Theory

Efficacy and Economic Evaluation of Weishi Qingjin Formula （苇石清金方）in the Treatment of Adult Community-Acquired Pneumonia with Phlegm-Heat Obstructing the Lung Syndrome：A Multicenter Retrospective Real-World Cohort Study

Syndrome Differentiation and Treatment of Cholinergic Urticaria from the Perspective of "Treating Fire Constraint by Dispersing It"

Construction and Application of a Real-World Cohort of Community-Acquired Pneumonia Based on a Multimodal Large-Scale Traditional Chinese Medicine Big Data Platform

Exploration on the Connotation and Application of the Three Aspects of "Dietary Inquiry" for "Appetite" "Eating Capacity" "Food Preference"

Related Author

No data

Related Institution

No data

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰