Effect of Bushen Tiaojing Decoction on Serum Leptin, Insulin and Tes tosterone of Polycystic Ovary Syndrome Model Rats

FENG Guangrong1; Hu XiaoHua2; Zhou Yanyan2

doi:10.13288/j.11-2166/r.2010.04.031

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Effect of Bushen Tiaojing Decoction on Serum Leptin, Insulin and Tes tosterone of Polycystic Ovary Syndrome Model Rats

更新时间：2021-11-17

- Effect of Bushen Tiaojing Decoction on Serum Leptin, Insulin and Tes tosterone of Polycystic Ovary Syndrome Model Rats
- Journal of Traditional Chinese Medicine Vol. 51, Issue 4, Pages: 356-358(2010)
- 作者机构：
  
  1. 河南省郑州市妇幼保健院
  2. 河南省中医院妇科
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2010.04.031
  CLC： R271.9
- Published：2010
- 稿件说明：
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[1]冯光荣,胡晓华,周艳艳.补肾调经汤对多囊卵巢综合征模型大鼠血清瘦素、胰岛素和睾酮的影响[J].中医杂志,2010,51(04):356-358.

FENG Guangrong1, Hu XiaoHua2, Zhou Yanyan2. Effect of Bushen Tiaojing Decoction on Serum Leptin, Insulin and Tes tosterone of Polycystic Ovary Syndrome Model Rats[J]. Journal of Traditional Chinese Medicine2010, 51(4): 356-358.
[1]冯光荣,胡晓华,周艳艳.补肾调经汤对多囊卵巢综合征模型大鼠血清瘦素、胰岛素和睾酮的影响[J].中医杂志,2010,51(04):356-358. DOI： 10.13288/j.11-2166/r.2010.04.031.

FENG Guangrong1, Hu XiaoHua2, Zhou Yanyan2. Effect of Bushen Tiaojing Decoction on Serum Leptin, Insulin and Tes tosterone of Polycystic Ovary Syndrome Model Rats[J]. Journal of Traditional Chinese Medicine2010, 51(4): 356-358. DOI： 10.13288/j.11-2166/r.2010.04.031.

摘要

目的探讨补肾调经汤改善多囊卵巢综合征（PCOS）排卵状况的作用机制。方法选用80只雌性SD大鼠

建立PCOS大鼠模型

随机分为空白组、模型组、二甲双胍组、补肾调经汤高剂量组、低剂量组

每组10只

其余大鼠剔除。观察各组大鼠血清瘦素、胰岛素和睾酮激素的变化。结果补肾调经汤高剂量组、低剂量组均可以使PCOS大鼠血清瘦素、胰岛素、睾酮降低

补肾调经汤高剂量组与二甲双胍组在降低瘦素、胰岛素和睾酮水平方面作用相近。结论补肾调经汤可能通过对瘦素、胰岛素、睾酮的调节促进PCOS大鼠排卵。

Abstract

Objective To observe the effect and mechanism of Bush en Tiaojing Decoction （Decocti on for reinforcing the kidney and regulating the menstruation） on ovulation of p olycystic ovary syndrome （PCOS） rats. Methods Eighty fe male SD rats were made PCOS models and randomized into blank group

model group

metformin group

Bushen Tiaojing Decoction high and low dose group s

with 10 ones in each and the remainders removed. The changes of serum leptin

ins ulin and testosterone in each group were observed. Results In Bushen Tiaoji ng Decoction high and low dose groups

serum leptin

insulin and testosteron e were all decreased. The effect of Bushen Tiaojing Decoction high dose group wa s similar with that of metformin group in decreasing leptin

insulin a nd testosterone. Conclusion Bushen Tiaojing Decoction c ould improve the ovulation of PCOS rats through regulating leptin

insulin

and testosterone.

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