Objective To study the effect and mechanism of Xinkai Kujiang method（TCM treatment with the pungent and bitter herbs to regulate the gastrofunctions）on the functional dyspepsia（FD）rats.Methods Twenty-four rats were randomized into control group

model group

and Weikangning（herbal medicine for dyspepsia）group

with 8 in each.After a 7-day adaptive feed

the FD models were made with the clipping tail stimulation.Seven days after modeling

the Weikangning group was given Weikangning Capsule 0.625g/kg by gavage

twice a day

and the other two groups were given normal saline in the same dosage.The medication was appliey in succession for 12 days

and on the thirteenth day

the serum and gastric tissues were collected for detecting the lab indications:plasma motilin（MTL）

plasma nitric oxide（NO）

gastric tissue MTL

nitric oxide synthase（NOS）

and the expression of Cajal interstitial cells（ICC）and gastrointesinal smooth muscle cells（SMC）.Results Compared with the control group

the level of plasma MTL in the model group was significantly decreased

the level of NO significantly increased

and the expression of MTL

ICC and SMC positive neurons in the stomach myenteric nerve plexus was significantly weakened

but the expression of NOS positive neurons was significantly strengthened（P<0.01）.Compared with the model group

the level of plasma MTL in the Weikangning group was significantly increased

the level of NO significantly decreased

and the expression of MTL

ICC and SMC of the gastrotissues was significantly increased

but the expression of NOS was decreased（P<0.01）.Conclusion The effect of Xinkai Kujiang method on functional dyspepsia rats is related to the adjustment of gastrointestinal movement.