A Clinic Observation on 38 Patients with Obstructive Sleep Apnea Hypopnea Syndrome Treated by Shengxian Decoction in Combination with Duxil

SU Jun; LI Lei; ZHONG Liping; DENG Yinghui

doi:10.13288/j.11-2166/r.2010.07.047

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A Clinic Observation on 38 Patients with Obstructive Sleep Apnea Hypopnea Syndrome Treated by Shengxian Decoction in Combination with Duxil

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- A Clinic Observation on 38 Patients with Obstructive Sleep Apnea Hypopnea Syndrome Treated by Shengxian Decoction in Combination with Duxil
- Journal of Traditional Chinese Medicine Vol. 51, Issue 7, Pages: 600-602(2010)
- 作者机构：
  
  深圳流花医院内科
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2010.07.047
  CLC： R766
- Published：2010
- 稿件说明：
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[1]粟俊,李磊,钟力平,邓映辉.升陷汤联合都可喜治疗阻塞性睡眠呼吸暂停低通气综合征38例临床观察[J].中医杂志,2010,51(07):600-602.

SU Jun, LI Lei, ZHONG Liping, et al. A Clinic Observation on 38 Patients with Obstructive Sleep Apnea Hypopnea Syndrome Treated by Shengxian Decoction in Combination with Duxil[J]. Journal of Traditional Chinese Medicine2010, 51(7): 600-602.
[1]粟俊,李磊,钟力平,邓映辉.升陷汤联合都可喜治疗阻塞性睡眠呼吸暂停低通气综合征38例临床观察[J].中医杂志,2010,51(07):600-602. DOI： 10.13288/j.11-2166/r.2010.07.047.

SU Jun, LI Lei, ZHONG Liping, et al. A Clinic Observation on 38 Patients with Obstructive Sleep Apnea Hypopnea Syndrome Treated by Shengxian Decoction in Combination with Duxil[J]. Journal of Traditional Chinese Medicine2010, 51(7): 600-602. DOI： 10.13288/j.11-2166/r.2010.07.047.

摘要

目的观察升陷汤联合都可喜治疗肺脾气虚型阻塞性睡眠呼吸暂停低通气综合征（OSAHS）的临床疗效。方法将68例患者随机分为两组

对照组（30例）口服都可喜治疗

治疗组（38例）在对照组基础上加服升陷汤加减治疗。两组均治疗10天。观察两组患者治疗前后临床症状积分变化

并分别于治疗前后行多导睡眠图（PSG）检查

观察记录总睡眠时间、低通气总时间、平均心率

计算每小时睡眠时间内90%以下血氧饱和度次数、整晚90%以下血氧饱和度持续总时间及呼吸暂停指数（AHI）和低通气指数（HI）。结果治疗组主要临床症状均较治疗前明显改善（P<0.05或P<0.01）

对照组除纳呆、便溏、苔白、脉濡弱外

其他症状亦较治疗前明显改善（P<0.05或P<0.01）;治疗后两组患者主要临床症状改善程度比较

治疗组优于对照组（P<0.05）。除平均心率外

治疗组治疗后PSG检查主要指标均较治疗前有所改善（P<0.05或P<0.01）

对照组各指标中仅90%以下血氧饱和度次数、90%以下血氧饱和时间较治疗前有改善（P<0.05或P<0.01）;两组治疗后比较

治疗组睡眠时间延长程度以及HI、低通气总时间、90%以下血氧饱和度次数、90%以下血氧饱和时间降低程度均优于对照组（P<0.05）。结论升陷汤联合都可喜治疗肺脾气虚型OSAHS有较好的疗效。

Abstract

Objective To observe the effect of Shengxian Decoction （Decoction for lifting the depressed organs） in the treatment of 38 patients with obstructive sleep apnea hypopnea syndrome （OSAHS） in the TCM syndrome of qi deficiency of the lung and spleen. Methods Totally 68 patients were randomized into a control group （30 cases） treated by Duxil for oral taking and a treatment group （38 cases） treated by Duxil and Shengxian Decoction for 10 days. The changes in the symptom scores of both groups after treatment were observed. The polysomnogram （PSG） was applied before and after treatment to record the total sleep time

hypopnea total time

and average heart rate to calculate the times when oxygen saturation was less than 90% in each hour sleep time

the total continuous time when oxygen saturation was less than 90% in the whole night

apnea-hypopnea index （AHI）

and hypopnea index （HI）. Results After treatment

the main symptoms in the treatment group were significantly improved （P<0.05 or P<0.01）

the symptoms in the control group were also significantly improved except poor appetite

loose stools

white tongue coating

and soft thready weak pulse （P<0.05 or P<0.01）. The improvement of the treatment group was more significant than that of the control group （P<0.05）. Except the average heart rate

the main PSG indices of the treatment group were all improved than before treatment （P<0.05 or P<0.01）

while in the control group

only the times when oxygen saturation was less than 90% in each hour sleep time and the total continuous time when oxygen saturation was less than 90% in the whole night were improved than before treatment （P<0.05 or P<0.01）. To compare the two groups

the prolonged sleep time

hypopnea total time

and the decreased times when oxygen saturation was less than 90% in each hour sleep time and the decreased total continuous time when oxygen saturation was less than 90% in the whole night of the treatment group were better than those of the control group （P<0.05）. Conclusion Shengxian Decoction is effective for OSAHS in the TCM syndrome of qi deficiency of the lung and spleen.

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