Analysis on Urine Metabolomics of Coronary Heart Disease Patients with the Heart Blood Stasis Syndrome

JIAN Weixiong; YUAN Zhaokai; HUANG Xianping; CHEN Qinghua; ZHENG Jinghui; LI Yonghua; WANG Liping

doi:10.13288/j.11-2166/r.2010.08.025

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Analysis on Urine Metabolomics of Coronary Heart Disease Patients with the Heart Blood Stasis Syndrome

更新时间：2021-11-17

- Analysis on Urine Metabolomics of Coronary Heart Disease Patients with the Heart Blood Stasis Syndrome
- Journal of Traditional Chinese Medicine Vol. 51, Issue 8, Pages: 729-732(2010)
- 作者机构：
  
  湖南中医药大学中医诊断研究所
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2010.08.025
  CLC： R259
- Published：2010
- 稿件说明：
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[1]简维雄,袁肇凯,黄献平,陈清华,郑景辉,李勇华,王丽萍.冠心病心血瘀阻证尿液代谢组学的检测分析[J].中医杂志,2010,51(08):729-732.

JIAN Weixiong, YUAN Zhaokai, HUANG Xianping, et al. Analysis on Urine Metabolomics of Coronary Heart Disease Patients with the Heart Blood Stasis Syndrome[J]. Journal of Traditional Chinese Medicine2010, 51(8): 729-732.
[1]简维雄,袁肇凯,黄献平,陈清华,郑景辉,李勇华,王丽萍.冠心病心血瘀阻证尿液代谢组学的检测分析[J].中医杂志,2010,51(08):729-732. DOI： 10.13288/j.11-2166/r.2010.08.025.

JIAN Weixiong, YUAN Zhaokai, HUANG Xianping, et al. Analysis on Urine Metabolomics of Coronary Heart Disease Patients with the Heart Blood Stasis Syndrome[J]. Journal of Traditional Chinese Medicine2010, 51(8): 729-732. DOI： 10.13288/j.11-2166/r.2010.08.025.

摘要

目的寻找冠心病（CHD）心血瘀阻证尿液代谢产物谱

综合分析CHD心血瘀阻证的代谢途径。方法 1运用GC-MS鉴定心血瘀阻证组和非心血瘀阻证组、健康组3组尿液代谢产物

通过对不同组之间代谢产物含量的变化进行主成分分析、偏最小二乘法分析。2综合分析CHD心血瘀阻证代谢途径。结果 1主成分分析:3组样本主成分得分显示分聚于椭圆形得分图的3个区域。尿液19种代谢产物中甘油、油酸酰胺、葡萄糖、丙酮等物质含量升高

而马尿酸、木糖醇降低。2偏最小二乘法分析:显示健康组远离心血瘀阻证组与非心血瘀阻证组

心血瘀阻证组与非心血瘀阻证组位置比较靠近可以判别他们同属一类;从标准化偏最小二乘系数图可见心血瘀阻证组与、甘油、油酸酰胺高度正相关

与马尿酸、木糖醇高度负相关。按照VIP值依次排列各变量依次是葡萄糖、甘油、木糖醇、马尿酸、油酸酰胺和丙酮。3差异性分析:有明显变化的代谢产物中

葡萄糖、甘油、油酸酰胺、丙酮在冠心病中均有不同程度升高

以心血瘀阻证中增高最为明显（P<0.01）;其中甘油、油酸酰胺、丙酮在非心血瘀阻证组与健康组比较也具有统计学差异（P<0.01）;核糖醇、马尿酸在心血瘀阻证组和心血瘀阻证组中均降低（P<0.01）

而以心血瘀阻证组降低最为明显（P<0.01）。结论 1葡萄糖、甘油、木糖醇、马尿酸、油酸酰胺、丙酮为CHD心血瘀阻证尿液生物代谢产物谱。2CHD心血瘀阻证代谢途径涉及脂质代谢紊乱以及应激因素

同时也与肝肾有一定相关性。

Abstract

Objective To study on the uric metabolites of coronary heart disease（CHD）patients with heart blood stasis syndrome in TCM and analyze comprehensively the metabolic pathway of heart blood stasis syndrome.Methods ①GC-MS was adopted to detect the uric metabolites of CHD patients with heart blood stasis syndrome

CHD patients without heart blood stasis syndrome

and healthy people.The principal component analysis（PCA）and partial least squares（PLS）analysis were done to study the changes of uric metabolites of different groups.②The metabolic pathway of heart blood stasis syndrome of CHD was analyzed comprehensively.Results ①PCA:The principal component scores of the three groups were distributed in three regions in the oval score graph respectively.Of the 19 uric metabolites

the contents of glycerol

oleamide

glucose

and acetone were increased and those of hippuric acid and xylitol were decreased.② PLS:The result of healthy people was far from those of CHD patients with and without heart blood stasis syndrome

the latter two groups tended to be of a same category.It could be seen from the standardized PLS coefficient graph that there was a positive correlation between heart blood stasis syndrome and the level of glycerol and oleamide and a negative correlation with the level of hippuric acid and xylitol.According to VIP value

all variables were arranged in an order of glucose

glycerol

xylitol

hippuric acid

oleamide

and acetone.③Variability:In the uric metabolites of CHD patients

the content of glucose

glycerol

oleamide

and acetone was increased

especially in those with heart blood stasis（P<0.01）.Of them

there also existed a significant different in glycerol

oleamide and acetone of those CHD patients without heart blood stasis and healthy people（P<0.01）.Adonitol and hippuric acid in the CHD patients with and without blood stasis syndrome were both decreased

especially in those with blood stasis syndrome（P<0.01）.Conclusion ① The uric metabolites of CHD patients with heart blood stasis are glucose

glycerol

xylitol

hippuric acid

oleamide

and acetone.② From the uric metabolites

it is reflected that the metabolic pathway of heart blood stasis syndrome is related with the disorders of lipid metabolism and the stress

as well as the dysfunctions of kidney and liver.

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Related Institution

Liaoning University of Traditional Chinese Medicine

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