Objective To observe the syndrome manifestations of rabbit atherosclerosis models and explore the syndrome attribution rules of the models.Methods The 24 male Japanese rabbits were randomized into a control group（n=8）and a experimental group（n=16）.The control group was given normal feed

and the experimental group was treated with high-fat diet and immune injury and surgical injury through the femoral artery balloon.They were fed totally for 10 weeks.Vascular morphological changes and blood lipid determine were used to evaluate the models.The ear

tongue

eye

and the overall state of rabbits were regularly observed to see the changes of TCM syndromes.Results The rabbits of the experimental group gradually reduced the amount of activity in early stage.When the climate changed

their nasal secretion was increased

and they had wheezing breathing

fever and other common cold symptoms like red auricle.In the medium stage

the fatty plaque or belt around the eyes

cold auricle

and listlessness could be seen

and the blood fat was significantly higher than that of the control group.To the tenth week

the dark tongue with blood spots and purple cold auricle appeared in the rabbits of the experimental group.It was difficult to draw blood from the ear

and the emboli could be seen in the vessels of auricles.Compared with the control group

the oxidized low density lipoprotein and malondialdehyde of the experimental group were significantly increased

and the activity of superoxide dismutase decreased.Conclusion The syndromes of rabbit atherosclerosis models are in the changing state

in early stage they can be manifested as Qi deficiency

in middle stage the manifestation can be Qi deficiency with phlegm retention

and in late stage there will be Qi deficiency with blood stasis.The rule is similar to that of the pathogenesis of atherosclerosis in clinic.