Objective To observe the effect and possible mechanism of the Chinese medicines resolving masses and dredging meridians on gastric emptying of rats with diabetic nephropathy.Methods Eighty SD male rats were randomly divided into 5 groups:control group

model group

low dose treated group

middle dose treated group

and high dose treated group.Models of diabetes were induced by removing the left kidney and injecting streptozotocin （STZ） solution into abdominal cavity.The rats in the treated groups were given Chinese medicines 5.29g/（kg·d）

10.58g/（kg·d）

and 21.16g/（kg·d） respectively by intragastric administration

while the rats in the control and model groups were administered the same dose normal saline for 6 weeks.Gastric emptying rate

plasma leptin

and glucagon were detected at the end of the experiment.Results Compared with the control group

the gastric emptying rate in the model group was significantly lowered （P<0.05）

the level of leptin and glucagon was significantly increased.Compared with the model group

the Chinese medicines could significantly improve the gastric emptying rate and decrease the level of leptin and glucagon （P<0.05）.There was a clear negative correlation among the level of leptin

glucagon and the gastric emptying rate.Conclusion The Chinese medicines could significantly improve the gastric emptying rate of the rats with diabetic nephropathy.Its possible mechanism might be related to decrease of the plasma leptin and glucagon.