Objective To study the influence of collateral-qi stagnation /deficient stagnation syndrome type on atherosclerosis（AS）from the angle of neuro-endocrine-immune（NEI）network.Methods Collateral-qi stagnation /deficient stagnation syndromes model

AS model

and collateral-qi stagnation /deficient stagnation compound with AS model were established with Wistar rats.They were administered Tongxinluo Capsule（Capsule for treating cardiovascular diseases）and Simvastatin for intervention.Their NEI network indices and endothelial dysfunction indices were detected respectively to analyze the correlations between the NEI network indices and endothelial dysfunction indices of all rat models.Results The related factors of NEI network including angiotensin Ⅱ（Ang Ⅱ）

aldosterone（ALD）

and thyroxine（T4）had positive correlation with nitric oxide（NO）

while thyroid-stimulating hormone（TSH）

interleukin-1β（IL-1β）

interleukin-2（IL-2）

triiodothyronine（T3）

adrenocorticotrophic hormone（ACTH）

cortisone（CORT）

tumor necrosis factor-α（TNF-α）

corticotropin releasing hormone（CRH）

plasma renin activity（PRA）

and interleukin-6（IL-6）had a negative correlation with nitric oxide（NO）.TNF-α

IL-6

PRA

CORT

IL-1β

IL-2

ACTH

CRH

T3

and T4 had positive correlation with ET

while ALD

Ang Ⅱ

and TSH had a negative correlation with ET.The result of fuzzy clustering of endothelial function and NEI network indices in each intervention group showed that the Tongxinluo large-dose group was in the highest similarity with the normal group.Conclusion The syndrome factors of collateral-qi stagnation /deficient stagnation can make worse vascular lesions through affecting the NEI network steady-state.Different from western medicine

Tongxinluo Capsule has specific intervention on the imbalanced NEI network steady-state.