Objective To observe the effect of Qingyi Huaji（clearing pancreas and dissolving stasis）herbal decoction combined with transcatheter arterial chemotherapy（TAC）and radiotherapy in the treatment of advanced or metastatic pancreatic cancer.Methods Totally 80 pancreatic cancer patients received TAC（gemcitabine and cisplatin or oxaliplatin）and radiotherapy 36～40 Gy/1.8～2.0 Gy and they were randomized into herbal group（41 cases）and control group（39 cases）.The herbal group was administered Qingyi Huaji herbal decoction

8 weeks in succession.Objective effect

survival

and treatment-related adverse reaction of the two groups were compared.Results In the herbal group the median survival time was 5.1 months and was 4.2 months in the control group

and one-year survival rate was 9.8% and 5.1% respectively in two groups（P<0.05）.PR

SD and PD of the herbal group was 13.9%

33.3% and 52.8% respectively

while PR

SD and PD of the control group was no significant difference between groups.The treatment-related adverse reaction of the two groups was without significant difference.Conclusion Qingyi Huaji herbal decoction in combination with TAC may prolong the survival time of patients with advanced pancreatic cancer.