Objective To study the effect of Baoyuan Tongluo Formula （Formula for protecting the heart and removing obstruction of meridians） on cardiovascular events of hemodialysis patients.Methods In a single-centered

prospective

random-controlled study

the 43 uremia patients receiving maintenance hemodialysis were enrolled （22 in the treatment group and 21 in the control group） and Baoyuan Tongluo Formula was given to the treatment group additionally.The observation lasted for 8 weeks.The serum albumin

hemoglobin

total cholesterol

triglyceride

homocysteine

high sensitivity C-reactive protein （hs-CRP）

and four diagnostic information were collected every 4 weeks for analysis.Results Water-damp and dame-heat were the risk factors of cardiovascular events in hemodialysis patients.In the treatment group

the symptom score of the 6th and 8th week decreased

total cholesterol increased

and homocysteine decreased with significant difference （P<0.05）

while in the control group

there was no significant difference.In the 8th week

compared with before treatment

the serum albumin of the treatment group was increased significantly （P<0.05）

but that of the control group was decreased.Comparing with the 4th week

the hemoglobin of the treatment group in the 8th week was statistically increased （P<0.05）

but that of the control group was significantly decreased than before treatment.There were no significant changes in triglyceride and hs-CRP within 8 weeks.The survival rate of the treatment group without cardiovascular accident during the observation was 45.45%

while that of the control group was 28.57%

the difference was significant （P<0.05）.Conclusion The comprehensive treatment with Baoyuan Tongluo Formula is effective in improving the symptoms

increasing the levels of albumin and hemoglobin

decreasing the level of homocysteine and reducing the risk of cardiovascular events.