Experimental Study on the TCM Theory of "Lumbus Being the House of the Kidney"

JIN Feng1; HUANG Meng1; WU Caiqin1; LIANG Qianqian3; DING Guanghong1

doi:10.13288/j.11-2166/r.2011.06.018

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Experimental Study on the TCM Theory of "Lumbus Being the House of the Kidney"

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- Experimental Study on the TCM Theory of "Lumbus Being the House of the Kidney"
- Journal of Traditional Chinese Medicine Vol. 52, Issue 6, Pages: 511-514(2011)
- 作者机构：
  
  1. 复旦大学力学与工程科学系
  2. 上海市针灸经络研究中心
  3. 上海中医药大学附属龙华医院脊柱病研究所
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2011.06.018
  CLC： R274
- Published：2011
- 稿件说明：
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[1]金凤,黄猛,吴彩琴,梁倩倩,丁光宏.“腰为肾之府”中医理论的实验研究[J].中医杂志,2011,52(06):511-514.

JIN Feng1, HUANG Meng1, WU Caiqin1, et al. Experimental Study on the TCM Theory of "Lumbus Being the House of the Kidney"[J]. Journal of Traditional Chinese Medicine2011, 52(6): 511-514.
[1]金凤,黄猛,吴彩琴,梁倩倩,丁光宏.“腰为肾之府”中医理论的实验研究[J].中医杂志,2011,52(06):511-514. DOI： 10.13288/j.11-2166/r.2011.06.018.

JIN Feng1, HUANG Meng1, WU Caiqin1, et al. Experimental Study on the TCM Theory of "Lumbus Being the House of the Kidney"[J]. Journal of Traditional Chinese Medicine2011, 52(6): 511-514. DOI： 10.13288/j.11-2166/r.2011.06.018.

摘要

目的通过诱导大鼠直立体位引起腰椎病变的实验方法来观察腰与肾的相关性

并由此认识"腰为肾之府"这一理论机制。方法将24只SD大鼠随机分为正常组、直立组及恢复体位组各8只

采用肩关节离断术、抬高食物和水的方法诱导大鼠直立

制备大鼠直立模型

9周后以X线片、血糖浓度、体重、肾组织形态为指标

观察腰椎变化对肾脏的影响。结果大鼠直立后出现下腰椎间隙变窄

椎体前缘出现唇缘样增生。直立组大鼠体重、肾小球直径、周长均较正常组显著性下降（P<0.01）;直立组、恢复体位组的肾小球直径

周长较正常组均有显著性增加（P<0.01）;肾组织出现病理变化

肾小球较正常组显著性增大（P<0.01）。结论大鼠直立后腰椎的变化可引发肾组织病理改变

恢复体位后有所改善

因此腰与肾关系密切

用现代实验方法验证了"腰为肾之府"中医理论。

Abstract

Objective To observe the relationship between the lumbus and kidney through the experimental study on the lumbar pathological changes caused by long-term upright posture in rats

and to understand the TCM theory that the lumbus is the house of kidney.Methods Twenty-four SD rats were randomized into the normal group

the upright posture group

and the posture recovery group.The upright posture models were made with the shoulder joint amputation and elevated food and water.Nine weeks later

the changes in X-ray examination

blood glucose

body weight

and kidney morphology were observed to see the influence of pathological changes of lumbar vertebrae on the kidney.Results In the upright posture

the X-ray examination showed that the lower lumbar intervertebral spaces became narrowed and a labial-like hyperplasia appeared in the anterior margin of vertebrae.In the upright posture group

the body weight

diameter and perimeter significantly lowered than that of the normal group（P<0.01）.In the upright posture group and posture recovery group

diameter and perimeter increased significantly as compared with the normal group（P<0.01）.There existed pathological changes in the kidney tissues

and the size of glomerulus increased significantly（P<0.01）.Conclusion The pathological changes of lumbar vertebrae due to upright posture may cause the pathological changes in the kidney tissues and the posture recovery improves these pathological changes.There is a close relationship between the lumbus and kidney.The TCM theory that the lumbus is the house of kidney is proved through the very modern experiment.

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