Objective To study the correlation between the TCM syndromes of chronic glomerulonephritis（CGN）and tubulointerstitial fibrosis（TIF）related indices

i.e.serum fibronectin（FN）and collagen type Ⅳ（Col Ⅳ）.Methods Of the 180 CGN patients

90 with normal renal function and 90 with renal insufficiency were set in two groups respectively.Another 60 healthy subjects were set as normal control group.The CGN patients were diagnosed with TCM syndrome differentiation.The levels of blood urea nitrogen（BUN）and serum creatinine（SCr）

FN

and Col Ⅳ were determined and the correlations of them were analyzed.Results The CGN patients had low FN and high Col Ⅳ level in comparing with the normal control group（P<0.05）

those with renal insufficiency had lowered FN and significantly higher Col Ⅳ compared with those with normal renal function（P<0.05）.The level of BUN and SCr of CGN patients were negatively correlated with the level of FN and positively correlated with the level of Col Ⅳ（P<0.05）.In the renal insufficiency group

the level of FN of those who were with the spleen and kidney yang deficiency was decreased at most and the level of Col Ⅳ was increased most obviously（P<0.05）.The level of FN of those who were with the damp-heat was decreased at most and the level of Col Ⅳ of those who were with the blood stasis was increased most obviously（P<0.05）.Conclusion The CGN patients with normal renal function are mostly involved in the lung and kidney qi deficiency

while those with a renal insufficiency are mostly likely to have the spleen and kidney yang deficiency.There exists correlation between the TCM syndromes and level of FN and Col Ⅳ of CGN patients.