Effect of Herbal-cake-isolated Moxibustion on the Expression of Peroxisome Proliferator-activated Receptor γ in Aortic Endothelial Cells of Atherosclerotic Rabbits

CHANG Xiaorong1; ZHANG Liang2; YU Baosheng1; FU Ling2; YUE Zenghui1; HE Xinqun2

doi:10.13288/j.11-2166/r.2011.08.016

您当前的位置：

首页 >

文章列表页 >

Effect of Herbal-cake-isolated Moxibustion on the Expression of Peroxisome Proliferator-activated Receptor γ in Aortic Endothelial Cells of Atherosclerotic Rabbits

更新时间：2021-11-17

- Effect of Herbal-cake-isolated Moxibustion on the Expression of Peroxisome Proliferator-activated Receptor γ in Aortic Endothelial Cells of Atherosclerotic Rabbits
- Journal of Traditional Chinese Medicine Vol. 52, Issue 8, Pages: 683-685(2011)
- 作者机构：
  
  1. 湖南中医药大学针灸推拿学院基础医学院
  2. 湖南中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2011.08.016
  CLC： R245
- Published：2011
- 稿件说明：
移动端阅览
[1]常小荣,张亮,郁保生,符凌,岳增辉,何新群.隔药饼灸对动脉粥样硬化兔主动脉内皮细胞过氧化酶体增殖物激活型受体γ的影响[J].中医杂志,2011,52(08):683-685.

CHANG Xiaorong1, ZHANG Liang2, YU Baosheng1, et al. Effect of Herbal-cake-isolated Moxibustion on the Expression of Peroxisome Proliferator-activated Receptor γ in Aortic Endothelial Cells of Atherosclerotic Rabbits[J]. Journal of Traditional Chinese Medicine2011, 52(8): 683-685.
[1]常小荣,张亮,郁保生,符凌,岳增辉,何新群.隔药饼灸对动脉粥样硬化兔主动脉内皮细胞过氧化酶体增殖物激活型受体γ的影响[J].中医杂志,2011,52(08):683-685. DOI： 10.13288/j.11-2166/r.2011.08.016.

CHANG Xiaorong1, ZHANG Liang2, YU Baosheng1, et al. Effect of Herbal-cake-isolated Moxibustion on the Expression of Peroxisome Proliferator-activated Receptor γ in Aortic Endothelial Cells of Atherosclerotic Rabbits[J]. Journal of Traditional Chinese Medicine2011, 52(8): 683-685. DOI： 10.13288/j.11-2166/r.2011.08.016.

摘要

目的观察隔药饼灸对动脉粥样硬化（AS）兔主动脉内皮细胞过氧化酶体增殖物激活型受体γ（PPARγ）的影响

探讨隔药饼灸延迟AS形成的作用机理。方法通过高脂饲料喂养及免疫损伤法建立兔AS模型。将75只新西兰大耳白兔随机分为5组

每组15只

即空白组（空白对照组）

模型组（AS模型组）

直接灸组（AS模型+艾炷直接灸）

隔药饼灸组（AS模型+隔药饼灸）

西药组（AS模型+阿托伐他汀）。治疗16周后检测兔主动脉内皮细胞PPARγ表达。结果模型组主动脉内皮细胞PPARγ的蛋白表达明显低于空白组、西药组和隔药饼灸组

且有统计学意义（P<0.05或P<0.01）;与直接灸组比较

西药组和隔药饼灸组PPARγ平均灰度值降低（P<0.05）;西药组与隔药饼灸组比较差异无统计学意义（P>0.05）。结论隔药饼灸能通过激活AS兔主动脉内皮细胞PPARγ的蛋白表达

起到延迟AS斑块形成的作用。

Abstract

Objective To observe the effect of herbal-cake-isolated moxibustion on the expression of peroxisome proliferator-activated receptor γ（PPARγ） in aortic endothelial cells of atherosclerosis（AS） rabbits and explore its functional mechanism in delaying the AS formation.Methods The AS models were established through high-fat diet and immunologic injury.Seventy-five New Zealand white rabbits were randomized into 5 groups

i.e.blank control group

model group

direct moxibustion group

herbal-cake-isolated moxibustion group

and atorvastatin group

with 15 rabbits in each.The expression of PPARγ in aortic endothelial cells was measured after treatment of 16 weeks.Results The PPARγ expression of the model group was lower than the blank control group

atorvastatin group

and herbal-cake moxibustion group with a significant difference（P<0.01 or P <0.05）.Compared with the direct moxibustion group

the average grey degree of PPARγ of the atorvastatin group and herbal-cake-isolated moxibustion group was decreased（P<0.05）.There was no significant difference between the atorvastatin group and herbal-cake-isolated moxibustion group（P>0.05）.Conclusion The herbal-cake-isolated moxibustion is able to activate the PPARγ expression in aortic endothelial cells of AS rabbits to delay the formation of atherosclerotic plaque.

关键词

Keywords

references

查看原文

Views

227

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Treating Vulnerable Atherosclerotic Plaque from the Perspective of "Abscess and Ulcer within the Vessels"

Effect of Jianpi Huazhuo Tiaozhi Granule（健脾化浊调脂颗粒）on Perivascular Adipose Tissue Browning and PI3K/AKT Pathway in the Aorta of Atherosclerosis Model Mice

Correlation Between Traditional Chinese Medicine Syndromes and Rheumatoid Arthritis with Atherosclerosis：A Multicenter Cross-Sectional Study

Time Sequential Differentiation and Treatment of Atherosclerosis Under the Guidance of the Theory of "Accumulation in Pulse"：Taking Coronary Heart Disease as An Example

Stage-Based Intervention in Atherosclerosis Using the "Attacking，Supplementing，Dispersing，Dissipating" Method Based on the Accumulation Syndrome Theory

Related Author

WANG Yajie

WU Min

ZHANG Zihao

WANG Zeping

LIU Longtao

WANG Zhuhua

WANG Yanfang

ZHONG Mingshu

Related Institution

Guang 'anmen Hospital，China Academy of Chinese Medical Sciences

Xiyuan Hospital，China Academy of Chinese Medical Sciences

Jiangxi University of Traditional Chinese Medicine

Ruijin Hospital of Traditional Chinese Medicine

Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰