Objective To investigate the effect and mechanism of Jinxin Concentrated Solution （Herbal decoction for pneumonia） enema on model rats with pneumonia induced by respiratory syncytial viruses （RSV）. Methods Fifty-six SD rats were randomized into seven groups

i.e. the normal control group

model control group

Jinxin high-dosage group

medium group

and low-dosage groups

pretreated group

and Ribavirin group

with 8 in each. The Jinxin high-dosage

medium-dosage

and low-dosage groups were given 0.50g/ml

0.99g/ml

and 1.98g/ml Jinxin Concentrated Solution enema respectively for 30min three days after using RSV nasal drop. The Ribavirin group was given Ribavirin Granule 1g/ml through intragastric administration. The pretreated group was given Jinxin Concentrated Solution enema at the same time of the first day of using RSV nasal drop with the same dosage and manipulation as that of the Jinxin medium-dosage group. All medicated groups were treated twice a day

1ml/100g each time. The pretreated group was treated for 10 days in succession and other groups for 7 days. The level of tumor necrosis factor α （TNF-α） in serum and secretory immuno-globulin A （SIgA） in bronchia alveolus lavage fluid were measured. Results Compared with the model control group and Jinxin low-dosage group

the level of TNF-α in the pretreated group and Jinxin medium-dosage group was significantly higher （P<0.05 or P<0.01）. The level of TNF-α in all Jinxin groups and Ribavirin group was without statistical difference （P>0.05）. Compared with the model control group and Ribavirin group

the level of SIgA in the pretreated group and Jinxin high-dosage and medium-dosage groups was significantly higher （P<0.01）. The level of SIgA in the Jinxin high-dosage group was significantly higher than that of the pretreated group and Jinxin medium-dosage and low-dosage groups （P<0.05 or P<0.01）. Conclusion The anti-virus effect of Jinxin Concentrated Solution enema is realized through increasing the secretion of TNF-α and SIgA of rats with pneumonia induced by RSV and there exists a dosage-effect relation.