Objective To explore the intervention effect of Dahuang Zhechong Pills [Pills containing Dahuang（Rhubarb） and Tubiechong（Ground Beetle） for dissolving blood stasis] on neurotransmitter in the formation stage of pulmonary fibrosis of rats.Methods Female Wistar rats were randomized into normal group

model group

and Dahuang Zhechong Pills group

with 12 in each.Except the normal group

the other rats were made pulmonary fibrosis models through endotracheal injection with Pingyangmycin（PYM）.The Dahuang Zhechong Pills group was treated with Dahuang Zhechong Pills solution in the density of 80mg/ml according to 1.5ml/100g body weight for intragastric feeding

while the model group was given the same amount distilled water for intragastric feeding

once a day.On the 28th day after modeling

the rats were put to death.The contents of dopamine（DA）

norepinephrine（NE）

and serotonin（5-HT） in the lung

hypothalamus

and hippocampus tissues of rats of all groups were compared with each other.Results The contents of NE

DA

and 5-HT in the lung and hypothalamus tissues and 5-HT in the hippocampus tissues of the rats of model group were statistically different from those of the normal group（P<0.05）.The contents of NE

DA

and 5-HT in the lung and hypothalamus tissues and NE

5-HT in the hippocampus tissues of the rats of Dahuang Zhechong Pills group were statistically different from those of the model group（P<0.05）.Conclusion In the formation stage of pulmonary fibrosis

the contents of DA

NE

and 5-HT in the lung and hypothalamus tissues and 5-HT in the hippocampus tissues are increased.Dahuang Zhechong Pills is effective in adjusting the contents of DA

NE

and 5-HT in the lung and brain tissues of rat models of pulmonary fibrosis.