Clinical Observation on Shugan Bushen Jieyu Decoction plus Maprotiline for 22 Cases of Depression

WEI Qing; WEI Xuhua

doi:10.13288/j.11-2166/r.2011.19.035

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Clinical Observation on Shugan Bushen Jieyu Decoction plus Maprotiline for 22 Cases of Depression

更新时间：2021-11-17

- Clinical Observation on Shugan Bushen Jieyu Decoction plus Maprotiline for 22 Cases of Depression
- Journal of Traditional Chinese Medicine Vol. 52, Issue 19, Pages: 1668-1670(2011)
- 作者机构：
  
  聊城市第四人民医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2011.19.035
  CLC： R749.4
- Published：2011
- 稿件说明：
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[1]魏青,魏绪华.舒肝补肾解郁汤联合马普替林治疗抑郁症22例临床观察[J].中医杂志,2011,52(19):1668-1670+1675.

WEI Qing, WEI Xuhua. Clinical Observation on Shugan Bushen Jieyu Decoction plus Maprotiline for 22 Cases of Depression[J]. Journal of Traditional Chinese Medicine2011, 52(19): 1668-1670.
[1]魏青,魏绪华.舒肝补肾解郁汤联合马普替林治疗抑郁症22例临床观察[J].中医杂志,2011,52(19):1668-1670+1675. DOI： 10.13288/j.11-2166/r.2011.19.035.

WEI Qing, WEI Xuhua. Clinical Observation on Shugan Bushen Jieyu Decoction plus Maprotiline for 22 Cases of Depression[J]. Journal of Traditional Chinese Medicine2011, 52(19): 1668-1670. DOI： 10.13288/j.11-2166/r.2011.19.035.

摘要

目的观察舒肝补肾解郁汤联合马普替林治疗抑郁症疗效及不良反应。方法 44例患者随机分为舒肝补肾解郁汤联合马普替林组（研究组）22例

单用马普替林组（对照组）22例。观察时间为6周。治疗前后以汉密顿抑郁量表（HAMD）、汉密顿焦虑量表（HAMA）减分率评定疗效。以副反应量表（TESS）评估不良反应。结果治疗前两组HAMD、HAMA评分值比较差异均无统计学意义（P>0.05）

治疗第1、2、4、6周末

两组HAMD、HAMA评分较治疗前均明显下降（P<0.05或P<0.01）;研究组治疗1、2、4、6周末HAMD、HAMA评分与对照组比较差异有统计学意义（P<0.05或P<0.01）。两组患者临床疗效的比较

研究组愈显率为81.8%。对照组愈显率为77.3%

研究组优于对照组（P<0.01）。两组患者起效时间比较

1周末研究组有11例

对照组8例;2周末研究组15例

对照组10例;4周末研究组有18例

对照组有16例

两组差异均有统计学意义（P<0.05）。研究组在口干、便秘、视力模糊、心悸、心电图异常等方面的不良反应明显减少

两者比较差异有统计学意义（P<0.01）。结论舒肝补肾解郁汤可增强马普替林对抑郁症的总体疗效

中西医结合治疗抑郁症优于单用马普替林片

并且毒副作用较小。

Abstract

Objective To observe the effect and adverse reaction of Shugan Bushen Jieyu Decoction（Decoction for soothing the liver

tonifying the kidney

and relieving the depression） plus maprotiline for depression.Methods A total of 44 depression patients were randomized into research group and control group

with 22 cases in each.The research group was administered Shugan Bushen Jieyu Decoction and maprotiline and the control group was given maprotiline only.The effect was assessed by Hamilton Depression Scale（HAMD） and Hamilton Anxiety Scale（HAMA）

and the adverse reaction was evaluated by Treatment Emergent Symptom Scale（TESS）.Results Before treatment

the scores of HAMD and HAMA in both groups were not significantly different（P>0.05）.At the end of the 1st

2nd

4th

and 6th week

the scores of HAMD and HAMA in both groups were significantly decreased（P<0.05 or P<0.01）.The scores of HAMD and HAMA in the research group at the end of the 1st

2nd

4th

and 6th week were statistically different from those of the control group（P<0.05 or P<0.01）.②The comparison of the clinical effect: the remarkably effective rate in the research group and the control group was 81.8% and 77.3% respectively.The effect of the research group was superior to that of the control group（P<0.01）. At the end of the 1st week

there were 11 effective cases in the research group and 8 effective cases in the control group;at the end of the 2nd week

there were 15 effective cases in the research group and 10 effective cases in the control group;and at the end of the 4th week

there were 18 effective cases in the research group and 16 effective cases in the control group

the difference between groups was statistically significant（P<0.05）.The adverse reaction such as dry mouth

constipation

blurred vision

palpitation

and abnormal ECG

etc.in the research group was significantly lowered

and it was significantly different from that of the control group （P<0.01）.Conclusion Shugan Bushen Jieyu Decoction can enhance the overall effect of maprotiline on depression and reduce its adverse reaction.The combination of Chinese medicine with western medicine is better in effect than the single use of western medicine and the untoward reaction is less.

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