Objective To explore the association of kidney deficiency with genetic susceptibility of type II diabetes mellitus （T2DM）. Methods Totally 188 cases of the first and second degrees of relatives of 62 probands

older than or equal to 35 years old

from the 62 T2DM families were screened out. The 250 family members

with the probands included

were divided into T2DM group （136 cases）

abnormal glucose tolerance group （52 cases）

and healthy family group （62 cases）. In addition

the other 60 people with normal glucose tolerance from the families without the history of diabetes were taken as the non-diabetes family healthy control group. According to the questionnaire on the 68 differentiation factors of kidney deficiency

for all groups

those without symptoms and signs were scored "0"

and those with symptoms and signs were scored "1". The difference of the total scores of factors of kidney deficiency in all groups was compared and the top 10 differentiation factors of kidney deficiency in each group were statistically processed. Results There was statistical difference in the averaged age between the T2DM group and the other 3 groups （P<0.01）. There was no statistical difference in the comparison of the 4 groups in the sex ratio （P>0.05）. The total score of differentiation factors of kidney deficiency of the T2DM group was significantly higher than that of the abnormal glucose tolerance group （P<0.01）. The total score of the related factors of kidney deficiency of the healthy family group was higher than that of the non-diabetes family healthy control group （P<0.01）. The appearance frequency of symptom lumbago in the T2DM group

abnormal glucose tolerance group

and healthy family group was always in the list of the top 10 factors

being 54.8%

53.2%

and 19.4% respectively

however

in the non-diabetes family healthy control group it was very low. Conclusion There is a genetic tendency existing in the kidney deficiency or kidney deficiency constitution in diabetes families

and this tendency is closely associated with the diabetes genetic susceptibility of the relatives of the family.