Clinical Analysis on the Clotting Indices of Malignant Tumor Patients and the Correlation between These Indices and Blood Stasis Syndromes

FU Qi; ZHANG Chenxi; YANG Guowang; WANG Xiaomin

doi:10.13288/j.11-2166/r.2011.23.013

您当前的位置：

首页 >

文章列表页 >

Clinical Analysis on the Clotting Indices of Malignant Tumor Patients and the Correlation between These Indices and Blood Stasis Syndromes

更新时间：2021-11-17

- Clinical Analysis on the Clotting Indices of Malignant Tumor Patients and the Correlation between These Indices and Blood Stasis Syndromes
- Journal of Traditional Chinese Medicine Vol. 52, Issue 23, Pages: 2024-2026(2011)
- 作者机构：
  
  首都医科大学附属北京中医医院肿瘤科
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2011.23.013
  CLC： R273
- Published：2011
- 稿件说明：
移动端阅览
[1]富琦,张晨曦,杨国旺,王笑民.恶性肿瘤患者凝血指标临床分析及其与血瘀证的相关性[J].中医杂志,2011,52(23):2024-2026+2030.

FU Qi, ZHANG Chenxi, YANG Guowang, et al. Clinical Analysis on the Clotting Indices of Malignant Tumor Patients and the Correlation between These Indices and Blood Stasis Syndromes[J]. Journal of Traditional Chinese Medicine2011, 52(23): 2024-2026.
[1]富琦,张晨曦,杨国旺,王笑民.恶性肿瘤患者凝血指标临床分析及其与血瘀证的相关性[J].中医杂志,2011,52(23):2024-2026+2030. DOI： 10.13288/j.11-2166/r.2011.23.013.

FU Qi, ZHANG Chenxi, YANG Guowang, et al. Clinical Analysis on the Clotting Indices of Malignant Tumor Patients and the Correlation between These Indices and Blood Stasis Syndromes[J]. Journal of Traditional Chinese Medicine2011, 52(23): 2024-2026. DOI： 10.13288/j.11-2166/r.2011.23.013.

摘要

目的探讨凝血指标在不同瘤种、不同分期的恶性肿瘤患者中分布特点及其与中医血瘀证的相关性。方法通过回顾性调查

收集明确诊断为肺癌、胃癌、大肠癌、乳腺癌患者的临床资料

对不同瘤种、不同分期患者凝血指标及血瘀证进行比较分析。结果共收集合格病例351例

其中共有343例凝血异常占97.72%。与早期比较

晚期肺癌及胃癌纤维蛋白原（FIB）的升高分度明显增高（P<0.05）;与大肠癌、乳腺癌、胃癌比较

肺癌患者的FIB升高分度明显增高

以Ⅲ度为主（P<0.05或P<0.01）。与早期比较

晚期肺癌D-二聚体（D-D）升高者分度明显增高（P<0.05）;晚期各瘤种比较

与乳腺癌、胃癌比较

肺癌患者的D-D升高分度明显增高

以Ⅲ度为主（P<0.01）。与早期比较

晚期乳腺癌患者血瘀比例增高

且血瘀证分级明显增高（P<0.05）。晚期与大肠癌和胃癌比较

肺癌及乳腺癌血瘀证分级明显增高（P<0.05）。Logistic回归分析显示

血瘀证与FIB、纤维蛋白原降解产物（FDP）升高存在相关性（P<0.05）。结论恶性肿瘤患者普遍存在凝血异常

多数患者合并有"血瘀"证

其中

肺癌分期越晚高凝状态越重、血瘀程度越重;血瘀证与凝血指标FIB、FDP升高存在相关性。

Abstract

Objective To explore the distribution characteristics of clotting indices in the different tumors and different stages of tumors and the correlation between these indices and blood stasis syndromes of TCM. Methods Through the retrospective survey

the clinical data of patients with clear diagnosis of lung

stomach

large intestine

and mammary cancers were collected

and the clotting indices in the different tumors and different stages of tumors and the correlation between these indices and blood stasis syndromes of TCM were analyzed. Results Altogether the data of qualified 351 cases were collected

of which

343 were with clotting abnormalities

accounted for 97.72%. Compared with those of early stage

the increase of fibrinogen （FIB） of advanced lung and stomach cancers was significant （P<0.05）. Compared with those of the large intestine

mammary

and stomach cancers

the increase of FIB of lung cancer was more significant

mainly in the Ⅲ degree （P<0.05 or P<0.01）. Compared with those of early stage

the increase of D-dimer （D-D） of advanced lung cancer was significant （P<0.05）. In the comparison of advanced cancers

the increase of D-D of lung cancer was significant

mainly in the Ⅲ degree

compared with the mammary and stomach cancers （P<0.01）. Compared with those of early stage

the rate of blood stasis in the advanced mammary cancer was increased and the grade of blood stasis syndrome was significantly higher （P<0.05）. Compared with the advanced large intestine and stomach cancers

the grade of blood stasis syndrome of lung and mammary cancers was significantly higher （P<0.05）. Logistic regression analysis showed that there existed the correlation between the blood stasis syndrome and the increased FIB and fibrinogen degradation products （FDP）（P<0.05）. Conclusion Malignant tumor patients generally have clotting abnormalities and most of them are accompanied with blood stasis syndrome of TCM. And the more advanced the lung cancer is

the more heavier clotting state is

and the more serious the blood stasis is. There exists the correlation between the blood stasis syndrome and clotting indices FIB and FDP increase.

关键词

Keywords

references

查看原文

Views

697

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Application of Invigorating Blood and Dissolve Stasis in Treating Malignant Tumor Based on Blood Stasis Syndrome

Differentiation and Treatment of Chemotherapy-Induced Nausea and Vomiting with Traditional Chinese Medicine Based on the Theory of "Yin Qi Descends，While All Yang Qi Ascends"

Construction and Application of "Source-Pivot-Convergence" Pattern Identification and Treatment Model for Malignant Tumors

Effects of Yangxin Tongmai Formula （养心通脉方） on Methylation Key Genes and the PERK/ATF4/CHOP Signaling Pathway in Myocardial Tissue of Coronary Heart Disease Model Rats with Blood Stasis Syndrome

Construction of a Diagnostic Model for Coronary Heart Disease with Blood Stasis Syndrome Based on Objective Multi-Modal Data Fusion

Related Author

LUO Qinqin

LU Yeyun

WANG Lifang

JIN Guiyu

LI Borun

PANG Bo

LI Yi

SHEN Qian

Related Institution

Longhua Hospital,Shanghai University of Traditional Chinese Medicine

The Second People’s Hospital of Chongming County

Xiyuan Hospital，China Academy of Chinese Medical Sciences

Guang'anmen Hospital，China Academy of Chinese Medical Sciences

Affiliated Hospital of Chengdu University of Traditional Chinese Medicine

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰