Objective To observe the effect and safety of different doses of Dahuang Fuzi Xixin Decoction [Decoction of Dahuang（Radix et Rhizoma Rhei）

Fuzi（Radix Aconiti Praeparata）

and Xixin（Herba Asari）] on chronic renal failure（CRF） patients.Methods Thirty CRF patients were randomized into large-dose group and small-dose group with 15 in each.After the basic treatment for 4

6

weeks

they were administered large-dose or small-doses of modified Dahuang Fuzi Xixin Decoction respectively.The TCM symptom scores

indices of renal function

and after scores of quality of life of between the two groups was compared 4

8

and 12 weeks treatment.Results After treatment

the TCM symptom scores of both groups decreased

and the comparison of each time points with before treatment showed statistical difference（P

<

0.05 or P

<

0.01）.After 8 and 12 weeks’ treatment

the TCM symptom score of the large-dose group was significantly lowered than that of the small-dose group

and the difference between the two groups was statistically significant（P

<

0.05 or P

<

0.01）.After 12 weeks’ treatment

the serum creatinine was significantly lowered（P

<

0.01） and the estimated glomerular filtration rate（eGFR） was significantly increased（P

<

0.05） in the large dose group.After 12 weeks’ treatment

the comparison of creatinine and eGFR between the two groups was statistically different（P

<

0.05）.After 12 weeks’ treatment

the scores of quality of life of both groups were significantly increased（P

<

0.01） compared with before treatment.After 12 weeks’ treatment

the comparison between the two groups showed that the score of quality of life of the large-dose group was higher than that of the small-dose group

and the difference was statistically significant（P

<

0.05）.There was not adverse events related with treatment.Conclusion The modified Dahuang Fuzi Xixin Decoction is effective in improving the TCM symptoms

stabilizing the renal function

and improving quality of life of the patients.Compared with the small-dose

the effect of large-dose of Dahuang Fuzi Xixin Decoction is more significant.