Objective To discuss the intervention effect of Huazhuo Granules（Granules for dissolving turbidity） on the lipid metabolism of rat models with non-alcoholic fatty liver disease（NAFLD）.Methods Fifty rats were randomized into blank group

model group

rosiglitazone group

and Huazhuo Granules high-dose and low-dose group.The blank group was fed with standard feed

and the rest were given high fat feed for 8 weeks for setting up NAFLD models.Rosiglitazone group was given rosiglitazone 0.36mg/kg for gastric perfusion.Huazhuo Granules high-dose and low-dose group were given the granules 2.025 and 0.675g/kg respectively for gastric perfusion.The model group was given normal saline of the same volume.All groups were observed on the changes of weight

liver index

total cholesterol（TC）

triglyceride（TG）

free fatty acid（FFA）

tumor necrosis factor α（TNF-α）

and fatty degeneration of hepatocytes.Results The body weight of Huazhuo Granule hige-dose group decrease significantly after treatment（P<0.01）.Compared with the model group

the Huazhuo Granules high-dose group and the rosiglitazone group showed decrease in liver index

TG

TC and TNF-α（P<0.05 or P<0.01）.Conclusion Huazhuo Granules is effective in lowering TG

TC

and TNF-α of NAFLD rat models

thus improved their abnormal lipid metabolism and pathological changes.