Objective To evaluate the effect of cinobutacini injection plus gemcitabine and cisplatin on non-small cell lung cancer（NSCLC）.Methods A total of 217 NSCLC patients were randomized into treatment group

109 cases

and control group

108 cases.The control group was treated with cinobutacini 1000mg/m2 on the first and 8th day;cisplatin 80

1

00mg/m2 on the second and the third day;based on which

the treatment group was treated with cinobutacini injection 20ml via intravenous drip.One period of treatment was of 28 days.After 3 periods of treatment

the therapeutic effect

benefit rate

survival rate

time of tumor progression

quality of life

and adverse reactions were evaluated.Results The effective rate of the treatment group and the control group was 55.96% and 37.96% respectively

the difference between the two groups was statistically significant（P

<

0.05）.The median tumor progression of the treatment group and control group was 30 weeks and 24 weeks respectively

and the statistical difference was found between groups（P

<

0.05）.Compared with the control group

the survival rate of the treatment group in six months

one year

and two years was increased significantly with statistical difference（P

<

0.05）.In comparing respectively with before treatment

the quality of life of both groups was significantly improved（P

<

0.05）

but the comparison between the two groups after treatment showed no statistical difference（P

>

0.05）.To compare with the control group

the adverse reactions of the treatment group were significantly decreased（P

<

0.05）.Conclusion The cinobutacini injection plus gemcitabine and cisplatin is helpful in alleviating clinical symptoms and improving life quality of NSCLC patients.