Objective To explore the effect of Jinbei Rukang Tablet（Tablet for breast diseases） on the liver qi stagnation and kidney deficiency model of precancerous breast lesion.Methods The 70 SD rats were randomized into blank group（n=15）

control group（n=15）

model group（n=20）

and Jinbei Rukang Tablet group（n=20）.The liver qi stagnation and kidney deficiency model was prepared with DMBA jointed with multi-composite stress and cold w ater stress.Jinbei Rukang Tablet was given to the Jinbei Rukang Tablet group

while the other-groups were given normal saline.Thirty days later

bloo d collected from abdominal cavity and the breast tissue collected for pathologic al examination.HE staining was adopted for observing the pathological changes a nd ELLISA method adopted for detecting the level of corticosterone（CORT）

estra diol（E2）

and progesterone（P）.Results Comparing with the control group

there appeared a series of bi ological changes in the model group

and the level of CORT was significantly increased（P <0.05）.The incidence of visible tumors in the Jinbei Rukang Tablet group was s ignificantly less than that of the model group（P<0.05）

the pathological c hange s characterized by proliferation were significantly relieved

and the levels of CORT and E2 were significantly decreased（P<0.05） and the level of P was slightly increased（P<0.05） than those of the model group.Conclusion Jinbei Rukang Tablet can reduce the incidence of visible tumors of t he rats of liver qi stagnation and kidney deficiency model group of precancerous breast lesions

promote the pathological changes of precancerous lesions changi ng to hyperplasia

and adjust hormone levels to inhibit progression of disease.