Objective To observe the clinical effect and to discu ss the mechanism of Jingfukang Granule（Granule for cervical spondylosis） associated with vinpoc etine for intravenous infusion on the vertebral artery type of cervical spondylo sis（CSA） in the attack stage.Methods Sixty-two cases were randomized into a control group（30 cases） and a treatment group（32 cases）.The control group wa s treated with vinpocetine 30mg for intravenous infusion

the tr eatment group was given Jingfukang Granule additionally for oral taking

10g eac h time

3 times a day.The course of treatment was of 2 weeks.Then

the clinica l effect and the time of effect initiation of the two groups were observed

the dep th of vertebral artery（VA） and the changes of basilar artery（BA）

vascular pul sation index（PI）

plasma endothelin（ET）

and nitric oxide（NO） afte r treatment were observed.Results The total effective rate of the treatment group and the control group was 90.6% and 70.0%

respectively.The effect of the treatment group was superior to that of the control group（P<0.05）.The time of effect initiation of the treatment group was earlier than that of the control group

it was mostly within 3 days that the symptoms were stopped in development（P<0.05）.The blood flow in VA of both groups was significantly increased after treatment（P<0.01）

PI was significantly decreased（P<0.01）

while the improvement of all indices of the treatment group was significantly superior to that of the control grou p（P<0.01 or P<0.05）.The level of NO of both groups was significantly increased（P<0.01） and the level of ET was significantly decreased（P<0.01）.Co mpared wit h the control group after treatment

the levels of NO and ET of the treatment gr oup were both significantly different（P<0.05）.Conclusion Jingfukang Granule associated with vinpocetine is effective for CSA.Its functional mechanism is co rrelated with the improvement of haemodynamics of vertebral-basilar artery

the decrease of plasma ET

and increase of NO of the CSA patients in the attack stag e.