Objective To observe the effect of Qiliqiangxin Capsu le on the mRNA exp ression of purinoceptor 2X1-7（P2X1-P2X7） in chronic heart failure（CHF） rats.Methods The CHF models were established by ligating th e anterior descending corona ry artery of 200 Wistar rats for 8 weeks.The rats were randomized into the mode l group

Qiliqiangxin Capsule large-dose group

Qiliqiangxin Capsule middle-do se group

Qiliqiangxin Capsule small-dose group

sham operation group and valsart a n group.After 4 weeks of successive administration

the mRNA expression of P2X1-P2X7 in the myocardial tissues of CHF model rats was detected by RT-PCR.Results Comparing with the sham group

the mRNA expressio n of P2X2

P2X4

P2X5 and P2X 6 in the model group was significantly decreased（P<0.05 or P<0.01）.C omparing w ith the model group

the mRNA expression of P2X2

P2X4

P2X5 and P2X6 in the Qil iqiangxin Capsule large-dose group was significantly increased（P<0.05 or P<0.01）.The mRNA expression of P2X3 in the model group was significantly increased on ly as compared with the sham group（P<0.05）

but the differences with other adm inistration groups were no statistically significant（P>0.05）.Conclusion Qiliqi a ngxin Capsule could regulate the mRNA expression of P2X

improve ventricular con traction function

increase heart output and inhibit heart failure

which maybe relevant to increasing the mRNA expression of P2X2

P2X4

P2X5 and P2X6.