Objective To observe the characteristic changes of the biochemical indicators related to the pathogenetic process in coronary heart disease（CHD）patients with unstable angina（UA）of phlegm-stasis binding syndrome.Methods Totally 120CHD patients with UA were divided into the phlegm-stasis binding group（65cases）and the qi deficiency with blood stasis group（55cases）according to syndrome differentiation.Twenty three healthy persons were chosen as the control group.The blood pressure

blood Glucose

blood lipid

thyroid function

coagulant function

angiotensinⅠ（AngⅠ）

high sensitivity Creactive protein（hs-CRP）

homocysteic acid（HCA）and inflammation mediators were observed.Results Comparing with the qi deficiency with blood stasis group

glycosylated hemoglobin（GHb）

total cholesterol（TC）

low density lipoprotein cholesterol（LDL-C）

prothrombin time（PT）and fibrinogen reaction time significantly increased in the phlegm-stasis binding group（P<0.05）

but the activated partial thromboplastin time significantly decreased（P<0.05）.There was no significant difference in blood lipid

coagulant function

blood Glucose

blood pressure

thyroid function

mediators of inflammation

AngⅠ

hs-CRP and HCA between the two groups（P>0.05）.Comparing with the control group

the contents of tumor necrosis factor-α（TNF-α）and laminin in other groups increased significantly（P<0.05）

but secreted immunoglobulin A（sIGA）decreased significantly（P<0.05）.Conclusion The disturbance of blood coagulation induced by hyperglycemia and hyperlipidemia may be an important pathogenetic process of UA with phlegm-stasis blinding syndrome.Inflammation immune reaction may play an important role in the pathogenetic process of blood-stasis syndrome.