Clinical Observation on Buqin Tablet Combined with Western Medicine for 17 Cases of Multidrug-Resistant Tuberculosis

YIN Liangsheng; ZHU Min; ZHOU Min

doi:10.13288/j.11-2166/r.2012.08.029

您当前的位置：

首页 >

文章列表页 >

Clinical Observation on Buqin Tablet Combined with Western Medicine for 17 Cases of Multidrug-Resistant Tuberculosis

更新时间：2021-11-17

- Clinical Observation on Buqin Tablet Combined with Western Medicine for 17 Cases of Multidrug-Resistant Tuberculosis
- Journal of Traditional Chinese Medicine Vol. 53, Issue 8, Pages: 669-672(2012)
- 作者机构：
  
  浙江省中西医结合医院结核科
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2012.08.029
  CLC： R521
- Published：2012
- 稿件说明：
移动端阅览
[1]尹良胜,朱敏,周敏.部芩片联合西药治疗耐多药肺结核17例临床观察[J].中医杂志,2012,53(08):669-672.

YIN Liangsheng, ZHU Min, ZHOU Min. Clinical Observation on Buqin Tablet Combined with Western Medicine for 17 Cases of Multidrug-Resistant Tuberculosis[J]. Journal of Traditional Chinese Medicine2012, 53(8): 669-672.
[1]尹良胜,朱敏,周敏.部芩片联合西药治疗耐多药肺结核17例临床观察[J].中医杂志,2012,53(08):669-672. DOI： 10.13288/j.11-2166/r.2012.08.029.

YIN Liangsheng, ZHU Min, ZHOU Min. Clinical Observation on Buqin Tablet Combined with Western Medicine for 17 Cases of Multidrug-Resistant Tuberculosis[J]. Journal of Traditional Chinese Medicine2012, 53(8): 669-672. DOI： 10.13288/j.11-2166/r.2012.08.029.

摘要

目的观察部芩片治疗耐多药肺结核患者的临床疗效及机制。方法将52例耐多药肺结核患者随机分为治疗组17例、微卡组17例、对照组18例

分别给予西药基础治疗加部芩片、西药基础治疗加微卡注射液及西药基础治疗

疗程6个月

观察各组治疗后临床疗效

并检测其治疗前、治疗后2个月、治疗后6个月白细胞介素12（IL-12）、干扰素（IFN-γ）含量。结果治疗后2个月治疗组、微卡组、对照组的有效率分别为82.35%、52.94%和41.18%

治疗组有效率明显高于对照组（P<0.05）

微卡组和对照组比较差异无统计学意义（P>0.05）。治疗后6个月治疗组、微卡组、对照组的有效率分别为88.24%、82.35%和70.59%

与对照组比较

治疗组和微卡组有效率均明显升高（P<0.05）;与治疗后2个月比较

治疗后6个月微卡组和对照组有效率均明显升高（P<0.05）

但治疗组差异无统计学意义（P>0.05）。与治疗前比较

治疗后2个月各组IL-12及IFN-γ含量差异均无统计学意义（P>0.05）。与治疗前比较

治疗后6个月治疗组及微卡组IL-12含量明显升高

差异有统计学意义（P<0.01）

各组IFN-γ含量明显升高（P<0.05）。治疗后6个月治疗组和微卡组IL-12及IFN-γ含量明显高于对照组（P<0.05或P<0.01）。结论部芩片可以明显提高耐多药肺结核患者的临床疗效;提高耐多药肺结核患者IL-12和IFN-γ含量

达到治疗耐多药肺结核的作用。

Abstract

Objective To study the therapeutic effect of Buqin Tablet [Tablet of Baibu（Radix Stemonae） and Huangqin（Radix Scutellariae）] for multidrug-resistant tuberculosis（MDR-TB） and its mechanism.Methods Fifty-two cases of MDR-TB were randomized into treatment group（17 cases）

Vaccae group（17 case） and control group（18 cases）.All groups were given anti-tuberculosis drugs.Buqin Tablet and Vaccae injection was added respectively in the treatment group and Vaccae group.The treatment lasted for 6 months.The therapeutic effect was observed and the contents of interleukin-12（IL-12） and interferon-α（IFN-α） were detected before and after 2 months and 6 months of treatment.Results After 2 months

the effective rate of the treatment group

Vaccae group and control group was 82.35%（14/17）

52.94%（9/17） and 41.18%（7/17） respectively.The effective rate of the treatment group was superior to that of control group（P<0.05）.There was no significant difference between the Vaccae group and control group（P>0.05）.After 6 months

the effective rate of the treatment group

Vaccae group and control group was 88.24%（15/17）

82.35%（14/17） and 70.59%（12/17） respectively.Comparing with the control group

the effective rates of the treatment group and Vaccae group increased significantly（P<0.05）.The effective rates of the control group and Vaccae group increased significantly after 6 months of treatment as compared with those after 2 months of treatment（P<0.05）.There was no significant difference in the treatment group between different treatment times（P>0.05）.After 2 months

the contents of IL-12 and IFN-α increased in the treatment group and Vaccae group without statistical significance（P>0.05）.After 6 months

the contents of IL-12 in all the groups increased significantly

especially in the treatment group and Vaccae group（P<0.01）.The contents of IFN-α increased significantly in all the groups（P<0.05）.Comparing with the control group

the contents of IL-12 and IFN-α increased in the treatment group and Vaccae group after 2 months of treatment

especially after 6 months of treatment（P<0.05 or P<0.01）.Comparing with the treatment group

the contents of IL-12 and IFN-α increased in the Vaccae group both after 2 months and 6 months of treatment without statistical significance（P>0.05）.Conclusion Buqin Tablet is effective for MDR-TB by increasing the contents of IL-12 and IFN-α.

关键词

Keywords

references

查看原文

Views

101

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Notoginseng Total Glucoside on the Dimethylnitrosamine Induced Hepatic Fibrosis of Rat Models

Mechanism of Liangxue Jiedu Decoction for Acute Aplastic Anemia

Gankang Mixture Combined with Interferon for 54 Cases of Chronic Hepatitis B

Efficacy and Economic Evaluation of Weishi Qingjin Formula （苇石清金方）in the Treatment of Adult Community-Acquired Pneumonia with Phlegm-Heat Obstructing the Lung Syndrome：A Multicenter Retrospective Real-World Cohort Study

Similarities and Differences between Myofascial Trigger Points and Sinew Knot：from the Perspective of the Channel Sinew Theory

Related Author

ZHANG Yongsheng 1

XU Shan 1

ZHAO Yufang 2

ZHU Feiye 1

YANG Shu-lian

ZHANG Wen-yi

WANG Dong-xia

et al.

Related Institution

Zhejiang University of Chinese Medicine

College of Chinese Medicine,Xiamen University

Chinese Medical Center for Haematology

河北省廊坊市中医医院血液内科、血液病中心实验室廊坊市银河北路108号

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰