Objective To evaluate the efficacy and safety of Comp ound Kushen Injection [compound injection of Kushen（Radix Sophorae Flavescentis）] combined w ith docetaxel for the elderly patients with non-small cell lung cancer（NSCLC）

Methods Sixty-eight elderly patients with NSCLC at th e Ⅲa or Ⅳ stage were randomiz ed into treatment group of 33 cases and control group of 35 cases.Both groups were given 35mg/m2 of docetaxel into 250ml normal saline intravenously for one hou r on the 1st and 8th day of the treatment course.The patients in the control group were orally taken 4mg of dexamethasone tablets

twice daily

from one day before the docetaxel administration and lasting for three days.The treatment grou p was given 10ml of Compound Kushen Injection intravenously for 14 consecutive days among the 21-day period.Both groups repeated 2 treatment periods and each period lasted for 21 days.The therapeutic effect

Karnofsky score

body weight and adverse effect were observed in both groups.Results The recent total efficiency of the treatment group and the control group was 24.2% and 22.9% respectively

with no significant difference（P>0.05）.The diseas e control rate of the treatment group and the control group was 69.7% and 57.1% respe ctively

with statistical significance（P<0.05）.After treatment

the reduct ion of Karnofsky score and body weight in the treatment group was significantly less than that of the control group（P<0.05）.The adverse reactions in the treatment group were lower and the differences between groups were statistically sig nificant in nausea and vomiting

reduction of white blood cell count

fatigue

l iver and kidney dysfunction and constipation（P<0.05）.Conc lusion The combo ther apy of Compound Kushen Injection and docetaxel is effective and safe for the eld erly patients with NSCLC and Compound Kushen Injection has attenuated synergies