Relation between Peripheral Blood T lymphocyte Subsets and Chinese Medicine Syndrome in HIV/AIDS Patients

CEN Yuwen1; LIU Ying2; JIA Weidong1; CHEN Xiejie1; ZHANG Jiansheng1; CHEN Meijun1; ZHANG Fuchun1; WANG Jian2

doi:10.13288/j.11-2166/r.2012.12.001

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Relation between Peripheral Blood T lymphocyte Subsets and Chinese Medicine Syndrome in HIV/AIDS Patients

更新时间：2021-11-17

- Relation between Peripheral Blood T lymphocyte Subsets and Chinese Medicine Syndrome in HIV/AIDS Patients
- Journal of Traditional Chinese Medicine Vol. 53, Issue 12, Pages: 1020-1024(2012)
- 作者机构：
  
  1. 广州市第八人民医院
  2. 中国中医科学院中医药防治艾滋病研究中心
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2012.12.001
  CLC： R259
- Published：2012
- 稿件说明：
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[1]岑玉文,刘颖,贾卫东,陈谐捷,张坚生,陈美君,张复春,王健.HIV/AIDS患者外周血T淋巴细胞亚群与中医证候的相关性分析[J].中医杂志,2012,53(12):1020-1024.

CEN Yuwen1, LIU Ying2, JIA Weidong1, et al. Relation between Peripheral Blood T lymphocyte Subsets and Chinese Medicine Syndrome in HIV/AIDS Patients[J]. Journal of Traditional Chinese Medicine2012, 53(12): 1020-1024.
[1]岑玉文,刘颖,贾卫东,陈谐捷,张坚生,陈美君,张复春,王健.HIV/AIDS患者外周血T淋巴细胞亚群与中医证候的相关性分析[J].中医杂志,2012,53(12):1020-1024. DOI： 10.13288/j.11-2166/r.2012.12.001.

CEN Yuwen1, LIU Ying2, JIA Weidong1, et al. Relation between Peripheral Blood T lymphocyte Subsets and Chinese Medicine Syndrome in HIV/AIDS Patients[J]. Journal of Traditional Chinese Medicine2012, 53(12): 1020-1024. DOI： 10.13288/j.11-2166/r.2012.12.001.

摘要

目的探讨人类免疫缺病毒/艾滋病（HIV/AIDS）患者外周血T淋巴细胞亚群与中医证候的相关性。方法采用艾滋病中医四诊信息采集表对133例HIV/AIDS患者进行临床调查与12个月的随访

使用人机结合的方法对四诊信息进行辨证分型

并同时监测T淋巴细胞亚群CD4+、CD8+计数

分析T淋巴细胞亚群各项指标与中医证候的相关性。结果 HIV/AIDS患者入组时出现频率居前4位的中医证型为肝郁气滞、气阴两虚、脾气虚弱、肝胃不和;随访12个月后出现频率居前4位的中医证型为肝郁气滞、气阴两虚、脾气虚弱、脾肾阳虚。其中入组时肝胃不和证患者的CD4+、CD8+计数均高于脾气虚弱证和气阴两虚证患者（P<0.05或P<0.01）

肝郁气滞证患者CD8+计数高于脾气虚弱证患者（P<0.01）;随访12个月后CD4+、CD8+计数在HIV/AIDS不同证型的患者之间比较差异无统计学意义（P>0.05）。入组时和高效抗逆转录病毒（HAART）治疗12个月后HIV/AIDS不同基本证型患者CD4+T淋巴细胞免疫重建差异均无统计学意义（P>0.05）;初始CD8+计数分层与HAART治疗12个月后的免疫学应答情况的关联系数r=0.384

具有统计学意义（P<0.001）。结论 AIDS患者外周血T淋巴细胞亚群CD4+、CD8+计数与中医证型密切相关。

Abstract

Objective To analyze the relation between peripheral blood T lymphocyte subsets and Chinese medicine syndrome in human immunodeficiency virus/acquired immune deficiency syndrome（HIV/AIDS） patients.Methods Totally 113 HIV/AIDS patients were investigated and followed up for 12 months.Man-machine system was used to identify the syndromes according to the diagnostic materials.CD4+ counts and CD8+ counts were monitored.The relation between peripheral blood T lymphocyte subsets and Chinese medicine syndrome was analyzed.Results At the beginning

the top four Chinese medicine syndromes were liver depression and qi stagnation syndrome

qi-yin deficiency syndrome

spleen qi deficiency syndrome and liver-stomach disharmony syndrome.After 12 months of follow-up

the top four Chinese medicine syndromes were liver depression and qi stagnation syndrome

qi-yin deficiency syndrome

spleen qi deficiency syndrome and spleen-kidney yang deficiency syndrome.At the beginning

CD4+ and CD8+ counts in liver-stomach disharmony syndrome were significantly higher than those in spleen qi deficiency syndrome and qi-yin deficiency syndrome（P<0.05 or P<0.01）

and CD8+ counts in liver depression and qi stagnation syndrome were significantly higher than that in spleen qi deficiency syndrome（P<0.01）.After 12 months of follow-up

there was no significant difference between syndromes in CD4+ and CD8+ counts（P>0.05）.There was no significant difference in immune reconstitution of CD4+ of all syndromes before and after highly active antiretroviral treatment（P>0.05）.There was statistical significance in correlation coefficient of initial CD8+ counts stratification and immunological response 12 months later（r=0.384

P<0.001）.Conclusion The CD4+ and CD8+ counts in peripheral blood T lymphocyte subsets are closely related to Chinese medicine syndrome in AIDS patients.

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