Clinical Study on Acupuncture Combined with Medication for 60 Cases of Perimenopausal Insomnia

HONG Yanli1; HE Guixiang1; WU Fei2

doi:10.13288/j.11-2166/r.2012.12.003

您当前的位置：

首页 >

文章列表页 >

Clinical Study on Acupuncture Combined with Medication for 60 Cases of Perimenopausal Insomnia

更新时间：2021-11-17

- Clinical Study on Acupuncture Combined with Medication for 60 Cases of Perimenopausal Insomnia
- Journal of Traditional Chinese Medicine Vol. 53, Issue 12, Pages: 1028-1031(2012)
- 作者机构：
  
  1. 南京中医药大学第一临床医学院
  2. 南京中医药大学教务处
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2012.12.003
  CLC： R246.3
- Published：2012
- 稿件说明：
移动端阅览
[1]洪艳丽,何贵翔,吴飞.针药结合治疗绝经过渡期失眠50例临床研究[J].中医杂志,2012,53(12):1028-1031+1045.

HONG Yanli1, HE Guixiang1, WU Fei2. Clinical Study on Acupuncture Combined with Medication for 60 Cases of Perimenopausal Insomnia[J]. Journal of Traditional Chinese Medicine2012, 53(12): 1028-1031.
[1]洪艳丽,何贵翔,吴飞.针药结合治疗绝经过渡期失眠50例临床研究[J].中医杂志,2012,53(12):1028-1031+1045. DOI： 10.13288/j.11-2166/r.2012.12.003.

HONG Yanli1, HE Guixiang1, WU Fei2. Clinical Study on Acupuncture Combined with Medication for 60 Cases of Perimenopausal Insomnia[J]. Journal of Traditional Chinese Medicine2012, 53(12): 1028-1031. DOI： 10.13288/j.11-2166/r.2012.12.003.

摘要

目的评价针药结合治疗绝经过渡期失眠（心肾不交型）的临床疗效及其对相关神经递质的影响。方法将绝经过渡期失眠（心肾不交型）患者140例随机分为中药组45例、针刺组45例、针药结合组50例

中药组口服益肾清心汤

每日1剂;针刺组选穴安眠、四神聪、神门、三阴交、申脉、照海进行电针治疗

隔日1次;针药结合组同时进行针刺结合中药治疗

各组均4周为1个疗程

4个疗程后评价疗效

并分别记录各组患者治疗前后Kupperman量表评分和匹兹堡睡眠质量指数（PSQI）评分

检测血清性激素、单胺类神经递质包括多巴胺（DA）、去甲肾上腺素（NE）、5-羟色胺（5-HT）、5-羟吲哚乙酸（5-HIAA）、γ-氨基丁酸（GABA）。结果针药结合组总有效率（74.0%）与中药组（66.7%）、针刺组（62.2%）比较差异有统计学意义（P<0.05）;而中药组与针刺组比较差异无统计学意义（P>0.05）。治疗后各组Kupperman量表各因子评分及总积分、PSQI各因子评分及总积分均较本组治疗前显著下降（P<0.01）

且针药结合组的改善程度优于中药组和针刺组（P<0.05）。治疗后各组患者血清性激素比较及与本组治疗前比较差异均无统计学意义（P>0.05）。治疗后各组血清单胺类神经递质水平与本组治疗前比较差异均有统计学意义（P<0.05）;治疗后针刺组DA、NE与针药结合组比较差异有统计学意义（P<0.05）

中药组DA、NE、5-HT与针药结合组比较差异有统计学意义（P<0.05）。结论针药结合比单纯中药或针刺改善绝经过渡期心肾不交型失眠疗效更佳

其机理与升高5-HT、5-HIAA、GABA含量、降低NE、DA合成相关。

Abstract

Objective To observe the therapeutic effect of acupuncture combined with medication for perimenopausal insomnia and its effect on the related neurotransmitters.Methods Totally 140 perimenopausal insomnia patients of non-interaction of the heart and kidney syndrome were randomized into the acupuncture group of 45 cases

Chinese medication group of 45 cases and acupuncture combined with medication group of 50 cases.The Chinese medication group was given Yishen Qingxin Decoction（decoction to boost the kidney and clear the heart） one dosage daily.The acupuncture group was given electro-acupuncture on Anmian（EX-HN） points

Sishencong（EX-HN1）

Shenmen（HT7）

Sanyinjiao（SP6）

Shenmai（BL62） and Zhaohai（KI6） every other day.The acupuncture combined with medication group was given the combo therapy.The treatment course lasted for 4 weeks.Four courses later

the therapeutic effect was analyzed according to Kupperman Scale and the Pittsburgh Sleep Quality Index（PSQI）.Meanwhile

serum sex hormones

dopamine（DA）

norepinephrine（NE）

5-hydroxytryptamine（5-HT）

5-hydroxyindoleacetic acid（5-HIAA） and γ-aminobutyric acid（GABA） were detected.Results The total effective rate of the acupuncture combined with medication group was 74.0%

which was superior to 66.7% of the Chinese medication group and 62.2% of the acupuncture group（P<0.05）.There was no significant difference between the Chinese medication group and the acupuncture group in the total effective rate（P>0.05）.After treatment

the factor and total scores in Kupperman Scale and PSQI in all groups were significantly decreased（P<0.01）

especially in the acupuncture combined with medication group（P<0.05）.The difference of serum sex hormones between pretreatment and after treatment was not statistically significant in all groups（P>0.05）.The differences of monoamine neurotransmitters between pretreatment and after treatment were statistically significant in all groups（P<0.05）.After treatment

the differences in DA and NE was statistically significant between the acupuncture group and the acupuncture combined with medication group（P<0.05）.The differences in DA

NE and 5-HT was statistically significant between the Chinese medication group and the acupuncture combined with medication group（P<0.05）.Conclusion Comparing with single acupuncture or medication

the combo therapy is more effective for perimenopausal insomnia of non-interaction of the heart and kidney syndrome.Its effect is relevant to the increase of 5-HT

5-HIAA and GABA and reduce of NE and DA.

关键词

Keywords

references

查看原文

Views

404

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Treatment of Chronic Insomnia Based on the Theory that "Spleen Fuctions as Wei Qi"：An Approach from the "Gut Microbiota-Circadian Rhythm-Ying-Wei Circulation" Perspective

ZHANG Zhiyuan's Experience in Treating Perimenopause-Related Insomnia with the Method of Regulating the Heart and Governing the Spirit

Effect of Hewei Anshen Formula （和胃安神方） on the Glu/GABA-Gln Cycle in the Suprachiasmatic Nucleus of Insomnia Model Rats

Treatment of Insomnia Using the Method of Resolving Depression and Regulating the Middle and Tranquillising Mind

Discussion on the Treatment of Insomnia from Liver Based on the Theory "Liver Governs Wei Qi （Defensive Qi）"

Related Author

GAO Yu

WANG Meng

LI Yuxi

SU Zhiying

ZHANG Xiaoxuan

YUAN Jiamin

XU Biyun

YANG Zhimin

Related Institution

The Second Clinical Medical College of Guangzhou University of Chinese Medicine

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine

First Clinical School of Shandong University of Traditional Chinese Medicine

Affiliated Hospital of Shandong University of Traditional Chinese Medicine

PLA Medical School

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰