Effect of Buzhang Naoxintong Capsule on Cardiac Function and Infarct Size in Rabbits with Acute Myocardial Infarction

CHEN Li 1; LI Zhishang2; LI Lixian2; LIU Shuling3; ZHAO Shuai 3; HU Xiaoqin3; CHEN Bojun3

doi:10.13288/j.11-2166/r.2012.15.028

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Effect of Buzhang Naoxintong Capsule on Cardiac Function and Infarct Size in Rabbits with Acute Myocardial Infarction

更新时间：2021-11-17

- Effect of Buzhang Naoxintong Capsule on Cardiac Function and Infarct Size in Rabbits with Acute Myocardial Infarction
- Journal of Traditional Chinese Medicine Vol. 53, Issue 15, Pages: 1315-1317(2012)
- 作者机构：
  
  1. 贵阳中医学院第一附属医院急诊与重症医学科
  2. 广东省中医院心脏中心
  3. 广东省中医院大学城医院急诊科
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2012.15.028
  CLC： R542.22
- Published：2012
- 稿件说明：
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[1]陈立,李志尚,黎丽娴,刘淑玲,赵帅,胡晓琴,陈伯钧.步长脑心通胶囊对急性心肌梗死兔心功能及梗死面积的影响[J].中医杂志,2012,53(15):1315-1317.

CHEN Li 1, LI Zhishang2, LI Lixian2, et al. Effect of Buzhang Naoxintong Capsule on Cardiac Function and Infarct Size in Rabbits with Acute Myocardial Infarction[J]. Journal of Traditional Chinese Medicine2012, 53(15): 1315-1317.
[1]陈立,李志尚,黎丽娴,刘淑玲,赵帅,胡晓琴,陈伯钧.步长脑心通胶囊对急性心肌梗死兔心功能及梗死面积的影响[J].中医杂志,2012,53(15):1315-1317. DOI： 10.13288/j.11-2166/r.2012.15.028.

CHEN Li 1, LI Zhishang2, LI Lixian2, et al. Effect of Buzhang Naoxintong Capsule on Cardiac Function and Infarct Size in Rabbits with Acute Myocardial Infarction[J]. Journal of Traditional Chinese Medicine2012, 53(15): 1315-1317. DOI： 10.13288/j.11-2166/r.2012.15.028.

摘要

目的探讨步长脑心通胶囊对急性心肌梗死（AMI）兔的心功能及梗死面积的作用。方法将42只新西兰兔随机分为假手术组、梗死对照组、药物组

每组14只。采用手术结扎左冠状动脉前降支（LAD）建立AMI兔模型

假手术组反穿线不结扎

各组均造模成功6只。假手术组、梗死对照组给予常规喂养

药物组在此基础上加入步长脑心通胶囊每次0.4g

每日3次

实验周期为3周

分别于术后2天、21天行心脏超声检查

检测左室舒张末期内径（LVDd）、左室收缩末期内径（LVDs）、左室射血分数（LVEF）

21天后处死家兔行心肌梗死面积测定。结果术后梗死对照组及药物组即刻可见左室前壁及心尖部颜色变暗

搏动减弱

心电图显示两个以上导联出现ST段持续弓背向上抬高并与T波融合;术后21天药物组与梗死对照组比较

LVEF增高（P<0.05）

而梗死面积明显降低（P<0.05）;与本组术后2天比较

药物组术后21天LVEF增加（P<0.05）。结论步长脑心通胶囊能够显著降低AMI兔术后21天心肌梗死面积

增加LVEF

改善心脏收缩功能。

Abstract

Objective To observe the effect of Buzhang Naoxintong Capsule on cardiac function and infarct size in rabbits with acute myocardial infarction.Methods Forty two New Zealand white rabbits were randomized into the sham operation group

control group and drug group

with 14rabbits in each.Ligation of the left anterior descending artery（LAD）was adopted to establish acute myocardial infarction model and the sham opertion group was not ligated.Six models were successfully established in each group.The sham operation group and control group were given conventional feed.Buzhang Naoxintong Capsule was added in the drug group

1capsule once

three times daily.The experimental period lasted for 3weeks.Echocardiography was given to the rabbits on the 2nd and 21st day of infarction.Left ventricular and diastolic diameter（LVDd）

left ventricular and systolic diameter（LVSd）

and left ventricular ejection fraction（LVEF）were determined.On the 21st day of infarction

the rabbits were killed and the infarct size was tested.Results Left ventricular anterior wall and apical was darkening and pulse was weakened after the ligation and model establishment.Electrocardiogram showed ST-segment arched upward and integrated with the T wave.On the 21st day of infarction

LVEF significantly increased（P<0.05）and the infarct size significantly decreased（P<0.05）in the drug group as compared with the control group.Comparing with the 2nd day of infarction

the LVEF significantly increased on the 21st day of infarction in the drug group（P<0.05）.Conclusion Buzhang Naoxintong Capsule could obviously decrease the infarct size

increase the LVEF and improve the cardiac function.

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