Effect of Didang Pill Combined with Western Medicine on Perihematoma Perfusion in Cerebral Hemorrhage Patients

JI Lin; WANG Xingchen; DAI Hongwei; GAN Jie; JI Xiaowei; WEI Qing; HE Yan

doi:10.13288/j.11-2166/r.2012.17.030

您当前的位置：

首页 >

文章列表页 >

Effect of Didang Pill Combined with Western Medicine on Perihematoma Perfusion in Cerebral Hemorrhage Patients

更新时间：2021-11-17

- Effect of Didang Pill Combined with Western Medicine on Perihematoma Perfusion in Cerebral Hemorrhage Patients
- Journal of Traditional Chinese Medicine Vol. 53, Issue 17, Pages: 1468-1471(2012)
- 作者机构：
  
  山东中医药大学第二附属医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2012.17.030
  CLC： R743.3
- Published：2012
- 稿件说明：
移动端阅览
[1]姬琳,王兴臣,戴宏伟,甘洁,纪孝伟,蔚青,贺燕.抵当丸联合西药对脑出血后血肿周围组织血流灌注的影响[J].中医杂志,2012,53(17):1468-1471+1474.

JI Lin, WANG Xingchen, DAI Hongwei, et al. Effect of Didang Pill Combined with Western Medicine on Perihematoma Perfusion in Cerebral Hemorrhage Patients[J]. Journal of Traditional Chinese Medicine2012, 53(17): 1468-1471.
[1]姬琳,王兴臣,戴宏伟,甘洁,纪孝伟,蔚青,贺燕.抵当丸联合西药对脑出血后血肿周围组织血流灌注的影响[J].中医杂志,2012,53(17):1468-1471+1474. DOI： 10.13288/j.11-2166/r.2012.17.030.

JI Lin, WANG Xingchen, DAI Hongwei, et al. Effect of Didang Pill Combined with Western Medicine on Perihematoma Perfusion in Cerebral Hemorrhage Patients[J]. Journal of Traditional Chinese Medicine2012, 53(17): 1468-1471. DOI： 10.13288/j.11-2166/r.2012.17.030.

摘要

目的探讨脑出血患者血肿周围组织血流的动态变化规律

观察抵当丸对脑出血患者血肿周围组织血流灌注的影响。方法脑出血患者60例

随机分为脑出血Ⅰ组和脑出血Ⅱ组各30例。脑出血Ⅰ组:单纯给予脑出血常规治疗;脑出血Ⅱ组:在常规治疗基础上于发病24h开始服用抵当丸

每日10丸

每次5丸

分早晚2次口服（吞咽困难者予鼻饲）。两组患者疗程均为28天。分别在治疗前及治疗后7天、14天、28天应用CT灌注成像技术测量血肿周围组织的局部脑血流量（rCBF）、局部脑血容量（rCBV）、对比剂平均通过时间（MTT）、对比剂峰值时间（TTP）;同时评定患者的神经功能缺损评分（NIHSS）、日常生活能力评分（BI）及中医证候评分。结果脑出血Ⅱ组和脑出血Ⅰ组rCBF、rCBV治疗后7天时最低

随后逐渐升高。MTT与TTP治疗后7天时达高峰

随后逐渐缩短;脑出血Ⅱ组治疗后14天、28天rCBF、rCBV显著高于脑出血Ⅰ组（P<0.05或P<0.01）

MTT、TTP显著低于脑出血Ⅰ组（P<0.05或P<0.01）。脑出血Ⅱ组治疗后14天、28天NIH-SS评分和BI评分与同时间脑出血Ⅰ组比较差异有统计学意义（P<0.05或P<0.01）。脑出血Ⅱ组中医证候评分在治疗后14天、28天显著低于脑出血Ⅰ组（P<0.05或P<0.01）。结论脑出血后血肿周围组织存在持续的低灌注状态

这种低灌注状态随时间改变呈现波动性的变化规律。抵当丸能显著改善脑出血后血肿周围组织血流灌注

对神经功能及中医临床证候的改善有促进作用。

Abstract

Objective To investigate the hemodynamic changes in intracerebral hemorrhage（ICH） patients and observe the effect of Didang Pill（Dead-On Pill） on perihematoma perfusion and prognosis in ICH patients.Methods Sixty ICH patients were randomized into group I（conventional treatment） and group II（conventional treatment combined with Didang Pill）

with 30 in each.The treatment course lasted for 28 days.The relative cerebralbolood flow（rCBF）

relative cerebralblood volume（rCBV）

mean transit time（MTT）

and time-to-peak（TTP） were detected by computed tomography（CT） perfusion before treatment and on the 7th

14th and 28th day of treatment.The Institutes of Health Stroke Scale（NIHSS）

Barthel Index（BI） and Chinese medical symptoms were assessed.Results The rCBF and rCBV in both groups were the lowest on the 7th day of treatment and then increased gradually.MTT and TTP reached a peak on the 7th day of treatment and then reduced gradually.The rCBF and rCBV in group II were significantly higher than those in group I on the 14th and 28th day of treatment（P<0.05 or P<0.01）.The MTT and TTP in group II were significantly lower than those in group I on the 14th and 28th day of treatment（P<0.05 or P<0.01）.The NIHSS scores in group II were significantly lower than those in group I on the 14th and 28th day of treatment（P<0.05 or P<0.01）.The BI scores in group II were significantly higher than those in group I on the 28th day of treatment（P<0.05 or P<0.01）.The scores of Chinese medical symptoms in group II were significantly lower than those in group I on the 14th and 28th day of treatment（P<0.05）.Conclusion There exists persistent hypoperfusion in the perihematoma after ICH.Hypoperfusion is fluctuated with time.Didang Pill could obviously promote the perihematoma perfusion after ICH

improve the nerve function and relieve Chinese medical symptoms.

关键词

Keywords

references

查看原文

Views

135

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Cross Electro-nape-acupuncture on cAMP-PKA Pathway in Medullary Tissue of Cerebral Hemorrhage Bulbar Injury Model Guinea Pigs

Clinical Observation on Supplemented Golden Coffer Alisma Decoction for 54 Cases of Cervical Vertigo with Phlegm Turbidity Obstructing the Center

Therapeutic Effect of Sequential Treatment of Integrated Chinese and Western Medicine on 56 Cases of Hemorrhagic Stroke

Influence of Pathogenesis "Stasis-heat" on the Pathological Condition and Prognosis of Cerebral Hemorrhage in Acute Stage

Effects of Liangxue Tongyu Formula （凉血通瘀方） on Serum Neurotrophic Factors and Oxidative Stress in Cerebral Hemorrhage Patients with Excess Syndrome

Related Author

WU Jianli

CAI Guofeng

LIU Guanping

LIANG Qun

JIA Kunping

JIN Zhiwei 2

WANG Shangzeng1

SUN Yongqiang1

Related Institution

The First Affiliated Hospital of Heilongjiang University of Chinese Medicine

Hanan Branch of the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine

Heilongjiang University of Chinese Medicine

China Academy of Chinese Medical Sciences

TCM Hospital of Henan Province

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰