Effect of Modified Simiao Powder on the Inflammatory Factors in Overweig ht Patients with Impaired Glucose Tolerance

LUO Tianjiong1; ZHANG Zhongai1; GAO Zhao1; ZHANG Jinchun1; WANG Hongliu2

doi:10.13288/j.11-2166/r.2012.19.010

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Effect of Modified Simiao Powder on the Inflammatory Factors in Overweig ht Patients with Impaired Glucose Tolerance

更新时间：2021-11-17

- Effect of Modified Simiao Powder on the Inflammatory Factors in Overweig ht Patients with Impaired Glucose Tolerance
- Journal of Traditional Chinese Medicine Vol. 53, Issue 19, Pages: 1655-1657(2012)
- 作者机构：
  
  1. 南京市中医院老年科
  2. 南京中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2012.19.010
  CLC： R259
- Published：2012
- 稿件说明：
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[1]骆天炯,张钟爱,高曌,章金春,王红柳.加减四妙散对超重糖耐量减低患者炎症因子的影响[J].中医杂志,2012,53(19):1655-1657.

LUO Tianjiong1, ZHANG Zhongai1, GAO Zhao1, et al. Effect of Modified Simiao Powder on the Inflammatory Factors in Overweig ht Patients with Impaired Glucose Tolerance[J]. Journal of Traditional Chinese Medicine2012, 53(19): 1655-1657.
[1]骆天炯,张钟爱,高曌,章金春,王红柳.加减四妙散对超重糖耐量减低患者炎症因子的影响[J].中医杂志,2012,53(19):1655-1657. DOI： 10.13288/j.11-2166/r.2012.19.010.

LUO Tianjiong1, ZHANG Zhongai1, GAO Zhao1, et al. Effect of Modified Simiao Powder on the Inflammatory Factors in Overweig ht Patients with Impaired Glucose Tolerance[J]. Journal of Traditional Chinese Medicine2012, 53(19): 1655-1657. DOI： 10.13288/j.11-2166/r.2012.19.010.

摘要

目的观察加减四妙散对湿热困脾型超重葡萄糖耐量减低（IGT）患者炎症因子的作用。方法超重IGT患者67例随机分为治疗组35例和对照组32例

治疗组在饮食运动指导的同时给予加减四妙散口服

对照组仅给予饮食运动指导

共观察1个月。比较两组治疗前后临床症状积分、空腹血糖（FBG）、餐后2小时血糖（2hPG）、空腹胰岛素（FINS）、白介素-6（IL-6）、脂联素（ADP）、体重指数（BMI）、胰岛素敏感性指数（IAI）的变化。结果两组患者在中医症状积分上较治疗前均有所改善（P<0.05）

治疗组患者BMI、FINS和IL-6水平较治疗前降低

ADP水平升高（P<0.05）。治疗组改善中医症状

降低FBG、FINS、IL-6水平和升高ADP、IAI水平均明显优于对照组（P<0.05）。结论加减四妙散可以通过调节炎症因子水平改善超重IGT患者胰岛素抵抗。

Abstract

ObjectiveTo observe the effect of Modified Simiao Po wder on the inflam matory factors in impaired glucose tolerance（IGT） patients with syndrome of dam p-heat encumbering the spleen.MethodsSixty-seven IG T patients were randomized into treatment group（35 cases） and the control group（32 cases）.The contro l group was given diet and exercise guidance.Modified Simiao Powder was added i n the treatment group.The treatment lasted for one month.The changes of the cl inical symptoms

fasting blood glucose（FBG）

2-hour postprandial blood glucose （2h-PBG）

fasting insulin（FINS）

interleukin-6（IL-6）

adiponectin（ADP）

bo dy mass index（BMI） and insulin activity index（IAI） were compared before and after treatment.ResultsThe scores of TCM symptoms were imp roved in both groups（P<0. 05）.The levels of BMI

FINS and IL-6 were significantly decreased while ADP i n creased in the treatment group（P<0.05）.Comparing with the control group

Modif ied Simiao Powder could significantly improve the scores of TCM symptom

decreas e the levels of FBG

FINS and IL-6 and increase the levels of ADP and IAI（P <0.0 5）.ConclusionModified Simiao Powder can improve the i nsulin resistance of IGT patients by modulating the inflammatory factors.

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