Objective To analyze the therapeutic effect of Modified Dachengqi Decoction （Major Qi Coordinating Decoction） combined with western medicine on acute pancreatitis （AP） .Methods Fifty-six cases of AP were randomized into treatment group and control group.The control group was given conventional therapy including food and water fasting

gastrointestinal decompression

parenteral nutrition

infection prevention and intervention

inhibition of gastric acid and pancreatic secretion. The treatment group was added with injection of supplemented Dachengqi Decoction by the jejunal feeding tube.All the indices were recorded and analyzed before and after treatment including serum amylase （AMY）

white blood cell （WBC）

C-reactive protein （CRP）

tumor necrosis factor-α （TNF-α）

interleukin-1 （IL-1）

body weight

albumin

prealbumin

ferritin

hemo- globin

and AMY recovery time

bloating relief time

complication rate

hospital stay and inpatient spending were recorded. Results AMY

WBC

CRP

TNF-αand IL-1decreased significantly in both groups after treatment （P<0.05）

especially in the treatment group （P<0.05） .The AMY recovery time

bloating relief time

hospital stay were shorter and inpatient spend- ing was lower in the treatment group than in the control group （P<0.05or P<0.01） .The intraperitoneal infection rate

pan- creatic pseudocyst formation rate and the incidence of severe bloating in the treatment group were significantly lower than those in the control group （P<0.05） .Albumin

prealbumin and ferritin increased significantly in both groups after treatment.After treatment

the body weight

albumin

prealbumin

feritin and hemoglobin in the treatment group were significantly higher than those in the control group （P<0.05） .Conclusion The early application of Modified Dachengqi Decoction combined with western medicine is safe and effective for AP

which could protect the intestinal mucosal barrier

improve the immune function and nutritional status

and shorten the course.