Effects of Kidney-Warming Spleen-Fortifying Formula on Renal Function,Hemorheology and Microcirculation in Diabetic Rats

CHEN Xiabo1; SHOU Qiyang2; GONG Wenbo1; ZHANG Lizong2; ZHOU Weimin2; ZHOU Kai 1; ZHANG Ye1; CHEN Minli 2

doi:10.13288/j.11-2166/r.2013.01.023

您当前的位置：

首页 >

文章列表页 >

Effects of Kidney-Warming Spleen-Fortifying Formula on Renal Function,Hemorheology and Microcirculation in Diabetic Rats

更新时间：2021-11-17

- Effects of Kidney-Warming Spleen-Fortifying Formula on Renal Function,Hemorheology and Microcirculation in Diabetic Rats
- Journal of Traditional Chinese Medicine Vol. 54, Issue 1, Pages: 59-61(2013)
- 作者机构：
  
  1. 宁波市中医院
  2. 浙江中医药大学动物实验研究中心
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2013.01.023
  CLC： R285.5
- Published：2013
- 稿件说明：
移动端阅览
[1]陈霞波,寿旗扬,龚文波,张利棕,周卫民,周开,张业,陈民利.温肾健脾方对糖尿病大鼠肾功能、血液流变性及微循环的影响[J].中医杂志,2013,54(01):59-61.

CHEN Xiabo1, SHOU Qiyang2, GONG Wenbo1, et al. Effects of Kidney-Warming Spleen-Fortifying Formula on Renal Function,Hemorheology and Microcirculation in Diabetic Rats[J]. Journal of Traditional Chinese Medicine2013, 54(1): 59-61.
[1]陈霞波,寿旗扬,龚文波,张利棕,周卫民,周开,张业,陈民利.温肾健脾方对糖尿病大鼠肾功能、血液流变性及微循环的影响[J].中医杂志,2013,54(01):59-61. DOI： 10.13288/j.11-2166/r.2013.01.023.

CHEN Xiabo1, SHOU Qiyang2, GONG Wenbo1, et al. Effects of Kidney-Warming Spleen-Fortifying Formula on Renal Function,Hemorheology and Microcirculation in Diabetic Rats[J]. Journal of Traditional Chinese Medicine2013, 54(1): 59-61. DOI： 10.13288/j.11-2166/r.2013.01.023.

摘要

目的探讨温肾健脾方治疗糖尿病肾病（DN）的可能作用机制。方法将链脲佐菌素诱导的DN大鼠36只随机分为模型对照组、温肾健脾组、缬纱坦组各12只

分别以蒸馏水10ml/kg、温肾健脾方20g/kg、缬沙坦胶囊25mg/kg

另取12只正常大鼠为正常对照组（蒸馏水10ml/kg）。连续给药8周后

检测各组大鼠体重、肾功能、血中蛋白水平、肾皮质层血流量及血液流变学指标。结果与正常对照组比较

模型对照组大鼠体重显著降低

葡萄糖（GLU）、尿素氮（BUN）显著上升

总蛋白（TP）、白蛋白（ALB）显著下降（P<0.01）

温肾健脾组和缬沙坦组显著改善BUN和TP水平（P<0.05或P<0.01）。模型对照组较正常对照组肾脏皮层微循环血流量显著升高（P<0.01）

温肾健脾组和缬沙坦组较模型对照组肾脏皮层微循环血流量显著下降（P<0.01）。模型对照组较正常对照组全血黏度、血浆黏度、卡松黏度及红细胞聚集指数均显著升高（P<0.05或P<0.01）;与模型对照组比较

温肾健脾组显著降低血浆黏度（P<0.05）。结论温肾健脾方治疗DN的机制可能与改善DN大鼠肾功能、降低血液黏稠度、改善肾微循环有关。

Abstract

Objective To observe the effects and possible mechanism of kidney-warming spleen-fortifying formula on diabetic nephropathy（DN） rats.Methods Thirty six DN rats induced by Streptozotocin（STZ） were randomized into model control group

kidney-warming spleen-fortifying group and valsartan group

with 12 in each.The rats were given 10ml/kg distilled water

20g/kg kidney-warming spleen-fortifying formula and 25mg/kg valsartan for 8 weeks respectively.Twelve normal rats were chosen as the normal control group（10ml/kg distilled water）.The body weight

renal function

serum protein level

renal cortex blood flow and hemorheology indexes were detected after 8weeks.Results Comparing with the normal control group

the body weights of DN rats were decreased

the levels of glucose（GLU）and blood urea nitrogen （BUN）were increased and the levels of total protein（TP）and albumin（ALB） were decreased in the model control group（P<0.01）.Comparing with the model control group

the levels of BUN were significantly decreased and the levels of TP were significantly increased in all administration groups（P<0.05or P<0.01）.Comparing with the normal control group

the renal cortex micro-circulation blood flow was significantly increased in the model control group （P<0.01）.Comparing with the model control group

the renal cortex microcirculation blood flow was significantly decreased in all administration groups（P<0.01）.Comparing with the normal control group

the whole blood viscosity

plasma viscosity and Casson viscosity was increased in the model control group（P<0.01）.Comparing with the model control group

the plasma viscosity was significantly decreased in the kidney-warming spleen-fortifying group （P<0.05）.Conclusion Kidney-warming spleen-fortifying formula can improve the renal function

reduce the blood viscosity and improve the renal microcirculation in DN rats.

关键词

Keywords

references

查看原文

Views

241

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of TCM Intervention on the Evolution of the Syndrome Factors in Early Diabetic Nephropathy

Effect of Different Classic Formulas on the Liver and Renal Function of Extrahepatic Cholestasis in Rats

Observation on the Effect of Bushen Huayu Tangshen Fang（补肾化瘀糖肾方） Combined with West Medicine in Treating 41 Cases of Qi-Yin Deficiency with Blood-stasis Syndrome of Ⅳ-stage Diabetic Nephropathy

Effects of Hedysarum Polybotys Saccharide on the Expressions of Vascular Endothelial Growth Factor and Pigment Epithelium-Derived Factor in Renal Tissue of db /db Mice

Differentiation and Treatment of Small Cell Lung Cancer from the Perspective of "Internal Wind in Hidden Circulation"

Related Author

YANG Hongtao5

WANG Yinghui1

ZHAO Jinxi2

WANG Shidong2

PANG Bo3

LI Jing3

GONG Qing3

HUANG Shan1

Related Institution

Wangjing Hospital,China Academy of Chinese Medical Sciences

TCM Hospital of Hebei Province

TCM Hospital of Qinhuangdao City

TCM Hospital of Baoding City

Peking University First Hospital

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰