Objective To study the mechanism of Pancreas-Clearing Toxin-Resolving Granules on severe acute pancreatitis （SAP）.Methods Forty-eighty SD rats were randomized into control group

model group

low-dose group

high-dose group

low-dose+Octreotide group and Octreotide group

with 8 in each.The SAP rat models were made with intraperitoneal injection of L-arginine hydrochloride.The control group and model group was gavaged with 7.5ml/kg of normal saline respectively after modeling.Drug administration was applied once every six hours

and the low-dose group and high-dose group was gavaged with 11.3g/kg and 56.5g/kg of Pancreas-Clearing Toxin-Resolving Granules respectively.The Octreotide group was given a subcutaneous injection of 0.5μg/100g Octreotide into the four limbs.The low-dose+Octreotide group was gavaged with low-dose of Pancreas-Clearing Toxin-Resolving Granules and injected with Octreotide subcutaneously.Drug administration was applied once every six hours

and the pancreatic tissue was drawn for histopathological observation after four times of administration. The contents of endotoxin and interleukin-6（IL-6）were detected.Results The pancreatic tissue structure was closely and the cell structure was completed in the control group.The normal structure of the pancreas was disappeared

the gland was necrosis

a large number of lymphocytes and neutrophils were infiltrative and subcapsular and interstitial was edema in the model group.The pancreatic lobules were focal necrosis or small necrosis in the low-dose group

high-dose group

low-dose+Octreotide group and Octreotide group.Comparing with the control group

the contents of endotoxin and IL-6were significantly increased in the model group（P<0.01）.Comparing with the model group

the contents of endotoxin and IL-6were significantly increased in the administrated groups（P<0.01）

especially in the low-dose+Octreotide group（P<0.05or P<0.01）. Conclusion Pancreas-Clearing Toxin-Resolving Granules is effective for SAP by decreasing the contents of endotoxin and IL-6 and reducing the release of inflammatory mediators

with better effect as combined with Octreotide.