Clinical Observation of Kidney-Supplementing Liver-Coursing Therapy for 30 Cases of Parkinson’s Disease Complicated by Mild to Moderate Depression with Liver-Kidney Yin Deficiency Syndrome

WANG Degang; ZHAO Hong; LU Zhengyu

doi:10.13288/j.11-2166/r.2013.02.009

您当前的位置：

首页 >

文章列表页 >

Clinical Observation of Kidney-Supplementing Liver-Coursing Therapy for 30 Cases of Parkinson’s Disease Complicated by Mild to Moderate Depression with Liver-Kidney Yin Deficiency Syndrome

更新时间：2021-11-17

- Clinical Observation of Kidney-Supplementing Liver-Coursing Therapy for 30 Cases of Parkinson’s Disease Complicated by Mild to Moderate Depression with Liver-Kidney Yin Deficiency Syndrome
- Journal of Traditional Chinese Medicine Vol. 54, Issue 2, Pages: 124-126(2013)
- 作者机构：
  
  上海中医药大学附属岳阳中西医结合医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2013.02.009
  CLC： R277.7
- Published：2013
- 稿件说明：
移动端阅览
[1]王德刚,赵虹,陆征宇.补肾疏肝法治疗肝肾阴虚型帕金森病伴轻中度抑郁30例临床观察[J].中医杂志,2013,54(02):124-126+154.

WANG Degang, ZHAO Hong, LU Zhengyu. Clinical Observation of Kidney-Supplementing Liver-Coursing Therapy for 30 Cases of Parkinson’s Disease Complicated by Mild to Moderate Depression with Liver-Kidney Yin Deficiency Syndrome[J]. Journal of Traditional Chinese Medicine2013, 54(2): 124-126.
[1]王德刚,赵虹,陆征宇.补肾疏肝法治疗肝肾阴虚型帕金森病伴轻中度抑郁30例临床观察[J].中医杂志,2013,54(02):124-126+154. DOI： 10.13288/j.11-2166/r.2013.02.009.

WANG Degang, ZHAO Hong, LU Zhengyu. Clinical Observation of Kidney-Supplementing Liver-Coursing Therapy for 30 Cases of Parkinson’s Disease Complicated by Mild to Moderate Depression with Liver-Kidney Yin Deficiency Syndrome[J]. Journal of Traditional Chinese Medicine2013, 54(2): 124-126. DOI： 10.13288/j.11-2166/r.2013.02.009.

摘要

目的观察补肾疏肝法治疗肝肾阴虚型帕金森病（PD）伴发轻中度抑郁患者的临床疗效。方法将60例患者随机分为治疗组和对照组各30例。对照组口服多巴制剂及盐酸舍曲林片

治疗组在此基础上加用补肾疏肝方药治疗

两组疗程均为12个月。比较两组患者治疗前后帕金森病统一评分量表（UPDRS）、汉密顿抑郁量表（HAMD）总分及HAMD筛选因子评分变化;观察两组患者治疗前后服用盐酸舍曲林和多巴制剂平均剂量及患者轻中度抑郁构成变化。结果治疗组治疗后UPDRS积分低于对照组（P<0.05）。治疗后治疗组HAMD积分低于治疗前

并且明显低于对照组治疗后（P<0.01）。治疗后治疗组患者抑郁消失11例

轻度抑郁15例

中度抑郁4例;对照组患者抑郁消失3例

轻度抑郁16例

中度抑郁11例

两组比较差异有统计学意义（P<0.05）。治疗后对照组HAMD筛选因子评分与本组治疗前比较差异无统计学意义（P>0.05）;治疗组HAMD筛选因子评分均低于治疗前

并且低于对照组治疗后（P<0.05或P<0.01）。结论补肾疏肝方药可改善肝肾阴虚型PD伴轻中度抑郁患者的运动症状、抑郁症状

减少患者每日服用盐酸舍曲林及多巴制剂的平均剂量。

Abstract

Objective To observe the therapeutic effect of kidney-supplementing liver-coursing therapy for Parkinson’s disease（PD） complicated by mild to moderate depression with liver-kidney yin deficiency syndrome.Methods Sixty PD patients were randomized into the treatment group and control group

with 30 in each.Both groups were given sertraline hydrochloride and levodopa according to the international medication guiding principle for PD.The treatment group was added with kidney-supplementing liver-coursing formula.The treatment course lasted for 12 months.The Unified Parkinson’s Disease Rating Scale（UPDRS） and Hamilton Depression Rating Scale（HAMD） were used to evaluate the therapeutic effect before and after treatment.The average dosages of sertraline hydrochloride and levodopa were observed in both groups before and after treatment.Results The total score of UPDRS was decreased in the treatment group after treatment

but comparison within group showed no significant difference（P>0.05）.The total score of UPDRS was increased in the control group after treatment

but comparison within group showed no significant difference（P>0.05）.The total score of UPDRS in the treatment group was lower than that in the control group after treatment（P<0.05）.The total score of HAMD was significantly decreased in the treatment group after treatment（P<0.01）.The total score of HAMD was decreased in the control group after treatment

but comparison within group showed no significant difference（P>0.05）.The total score of HAMD in the treatment group was lower than that in the control group after treatment（P<0.01）.There were 11 cases without depression

15 cases of mild depression and 4 cases of moderate depression in the treatment group after treatment.There were 3 cases without depression

16 cases of mild depression and 11 cases of moderate depression in the control group after treatment.There were significant differences between groups in the cases of mild and moderate depression after treatment（P<0.05）.Comparing within the control group

there was no significant difference in each factor score of HAMD（P>0.05）.All factor scores of HAMD were significantly deceased in the treatment group after treatment（P<0.05 or P<0.01）.All factor scores of HAMD in the treatment group were significantly lower than those in the control group after treatment（P<0.05 or P<0.01）.Conclusion Kidney-supplementing liver-coursing therapy can relieve the motor symptoms and depression of PD patients with liver-kidney yin deficiency syndrome and reduce the daily dosage of sertraline hydrochloride and levodopa.

关键词

Keywords

references

查看原文

Views

368

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

WANG Xixing's Experience in Differentiation and Treatment of Advanced Breast Cancer with Anxiety and Depression：Based on Shaoyang Pivot Theory

Efficacy and Safety of Acupuncture Combined with Levodopa in the Treatment of Parkinson's Disease： A Randomized Controlled Trial

Exploration of the Body-Mind Harmonization Strategy in Treatment of Psoriasis with Anxiety and Depression Based on the "Depression-Blood-Spirit" Transformation Theory

Dingchan Granule （定颤颗粒） for Paroxysmal Atrial Fibrillation with Syndrome of Qi Stagnation and Blood Stasis：A Randomized，Double-Blinded，Placebo-Controlled Clinical Trial

Treatment of Asthenospermia and Infertility with Liver Constraint and Kidney Deficiency in 45 Cases by Shugan Bushen Yulin Decoction （疏肝补肾毓麟汤） and Vitamin E Soft Capsules： A Multicenter Randomized Controlled Trial

Related Author

ZHAI Wenbo

WANG Xinyue

ZHANG Dongxin

SHI Zhiyao

GUO Yuyan

YANG Xi

王晞星

ZHU Jingyun

Related Institution

Shanxi Province Hospital of Traditional Chinese Medicine

The First Clinical College，Shanxi University of Chinese Medicine

Shanxi Provincial Institute of Traditional Chinese Medicine

Beijing Hospital of Traditional Chinese Medicine，Capital Medical University

Henan University of Chinese Medicine

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰