LU Yanli, JIN Li, SUN Dan. Clinical Observation of Xifeng Capsule for 19 Cases of Benign Childhood Epilepsy[J]. Journal of Traditional Chinese Medicine2013, 54(2): 121-123.
LU Yanli, JIN Li, SUN Dan. Clinical Observation of Xifeng Capsule for 19 Cases of Benign Childhood Epilepsy[J]. Journal of Traditional Chinese Medicine2013, 54(2): 121-123.DOI: 10.13288/j.11-2166/r.2013.02.026.
Clinical Observation of Xifeng Capsule for 19 Cases of Benign Childhood Epilepsy
Objective To observe the therapeutic effect of Xifeng Capsule(wind-extinguishing capsule) for children of benign epilepsy with centrotemporal spikes(BECTS) and the changes of electroencephalogram(EEG)
determine its effective difference with Carbamazepine(CBZ) and find the better antiepileptic drugs.Methods Thirty-seven cases of BECTS from pediatric outpatients were randomized into the Xifeng Capsule group(19 cases) and CBZ group(18 cases).The Xifeng Capsule group was given Xifeng Capsule
0.99g once
three times daily.The CBZ group was given 10-20mg/kg of CBZ daily.Both groups were treated for 6 months as one observation course.The therapeutic effect was observed after treatment and EEG was examined before and after treatment.Results The total effective rate of the Xifeng Capsule group and CBZ group was 84.21% and 83.33% respectively
with no significant difference between groups(P>0.05).After treatment
the epileptiform discharge frequencies of EEG in awake
slow-wave sleep and fast-wave sleep stage were significantly reduced in both groups(P<0.01).The focal discharge frequency in the Xifeng Capsule group was less than that in the CBZ group
but with no significant difference between groups(P>0.05).There were 15 cases(78.94%) in the Xifeng Capsule group and 11 cases(61.1%) in the CBZ group that did not occur focal discharge or declined in the frequency
but with no significant difference between groups(P>0.05).There were 14 cases(73.69%) in the Xifeng Capsule group and 11 cases(61.1%) in the CBZ group those focal discharge position changed
but with no significant difference between groups(P>0.05).Conclusion Xifeng Capsule is as effective as CBZ for BECTS in controlling clinical seizures and improving EEG.
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