Objective To observe the therapeutic effect and mechanism of Chinese medicine combined with acupoint injection in chronic urticaria patients.Methods Ninety cases of urticaria were randomized into group A

group B and group C.Group A was given Chinese medication.Group B was injected with 1 ml diphenhydramine and 2 ml Vitamin D2 and calcium colloidal injection on Zusanli（ST36

double） and Quchi（LI11

double） alternately.Group C was given Chinese medication and acupoint injection.One treatment course lasted for 14 days.Each group was given one treatment course per month for 3 courses.Thirty healthy controls were selected.The peripheral blood T cell subsets were detected and the therapeutic effect was observed.Results There were 6 cases（21.43%） cured

10 cases（35.71%） excellent

5 cases（17.86%） valid and 7 cases（25%） invalid in group A

with a total effective rate of 57.14%.There were 8 cases（27.59%） cured

8 cases（27.59%） excellent

5 cases（17.24%） valid and 8 cases（27.59%） invalid in group B

with a total effective rate of 55.17%.There were 11 cases（33.33%） cured

13 cases（39.39%） excellent

6 cases（18.18%） valid and 3 cases（9.09%） invalid in group C

with a total effective rate of 72.73%.The total effective rate of group C was superior to that of group A and group B（P<0.05）.Comparing with the control group

CD3+

CD4+ and CD4+/CD8+ was significantly lower in group A

group B and group C（P<0.05）

but CD8+ was significantly higher before treatment（P<0.05）.There was no significant difference between before and after treatment in CD3+ in group A

group B and group C（P>0.05）.There was a significant difference between before and after treatment in CD4+

CD8+ and CD4+/CD8+ in group A

group B and group C（P<0.05）.Comparing with group C

there was a significant difference in CD4+

CD8+ and CD4+/CD8+ in group A and group B after treatment（P<0.05）.Conclusion The combo therapy of Chinese medicine and acupoint injection is effective for chronic urticaria.It can regulate cellular immune function and improve T cell subsets.