Medical Innovation of Post Syndrom and Treatment Pharmacokinetics: A Study on Holism-Guided Reductionism

HUANG Xi; REN Ping

doi:10.13288/j.11-2166/r.2013.05.024

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Medical Innovation of Post Syndrom and Treatment Pharmacokinetics: A Study on Holism-Guided Reductionism

更新时间：2021-11-17

- Medical Innovation of Post Syndrom and Treatment Pharmacokinetics: A Study on Holism-Guided Reductionism
- Journal of Traditional Chinese Medicine Vol. 54, Issue 5, Pages: 365-368(2013)
- 作者机构：
  
  中南大学湘雅医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2013.05.024
  CLC： R289
- Published：2013
- 稿件说明：
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[1]黄熙,任平.后证治药动学的医药创新——整体导向还原论研究[J].中医杂志,2013,54(05):365-368.

HUANG Xi, REN Ping. Medical Innovation of Post Syndrom and Treatment Pharmacokinetics: A Study on Holism-Guided Reductionism[J]. Journal of Traditional Chinese Medicine2013, 54(5): 365-368.
[1]黄熙,任平.后证治药动学的医药创新——整体导向还原论研究[J].中医杂志,2013,54(05):365-368. DOI： 10.13288/j.11-2166/r.2013.05.024.

HUANG Xi, REN Ping. Medical Innovation of Post Syndrom and Treatment Pharmacokinetics: A Study on Holism-Guided Reductionism[J]. Journal of Traditional Chinese Medicine2013, 54(5): 365-368. DOI： 10.13288/j.11-2166/r.2013.05.024.

摘要

概述了20年来证治药动学的相关研究

即整体导向还原论研究。证治药动学能对方剂的吸收生物活性成分（吸收生物活性成分）定性、定量

生物方剂分析药理能阐明代表方剂疗效的主要吸收生物活性成分。随后研究工作的重心是以方剂吸收生物活性成分为枢纽的药学研究策略及其应用

包括方剂药动学与活性导向分离的研究、疗效相关最佳吸收生物活性成分比例作为方剂质量控制标准的研究及肝气郁结相关抑郁共病机理的研究。方剂吸收生物活性成分及其作用机理的深入研究

有利于开辟一条新药研发与发病机理研究的新途径

还可融合到"组分配伍"的科学研究中。

Abstract

To review the theory and application of the "syndrome and treatment pharmacokinetics" pharmaceutical innovation in the past twenty years

which is a holism-guided reductionism research. "syndrome and treatment pharmacokinetics" can examine the absorbed bioactive compound （ABC） of TCM prescription in vivo through the qualitative and quantitative analysis. Bioethnopharmaceutical analytical pharmacology （BAP） is an idea for elucidating ABC in traditional Chinese medicine （TCM） formula or herbal remedy. ABC is focused on as a hub of pharmacy strategy in the subsequent research

including ethnopharmacokinetic-and activity-guided isolation （EAGI）

as well as researches on ABC to infer the mechanism of depression comorbidity related to liver-qi stagnation. The in-depth study of ABC and its mechanism is help for opening up a new approach to research drug R&D and pathogenesis.In addition

our work can melts the TCM "components and combinations" together and assist each other in scientific research.

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Related Institution

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School of Traditional Chinese Medicine, Beijing University of Chinese Medicine

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