Study on Common Features of Damp-Heat Syndrome in Rheumatism Based on Metabolomics

ZHAO Tie1; YIN Tingting2; ZHANG Yingze1; LU Jin1; LI Ping1; WANG Guochun1; ZU Ning1; YAN Xiaoping1; ZHANG Xianglin1

doi:10.13288/j.11-2166/r.2013.07.015

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Study on Common Features of Damp-Heat Syndrome in Rheumatism Based on Metabolomics

更新时间：2021-11-17

- Study on Common Features of Damp-Heat Syndrome in Rheumatism Based on Metabolomics
- Journal of Traditional Chinese Medicine Vol. 54, Issue 7, Pages: 592-596(2013)
- 作者机构：
  
  1. 卫生部中日友好医院药学部
  2. 郑州大学附属郑州市中心医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2013.07.015
  CLC： R259
- Published：2013
- 稿件说明：
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[1]赵铁,殷婷婷,张英泽,陆进,李平,王国春,祖宁,阎小萍,张相林.基于代谢组学的强直性脊柱炎和痛风性关节炎湿热证共性特征研究[J].中医杂志,2013,54(07):592-596.

ZHAO Tie1, YIN Tingting2, ZHANG Yingze1, et al. Study on Common Features of Damp-Heat Syndrome in Rheumatism Based on Metabolomics[J]. Journal of Traditional Chinese Medicine2013, 54(7): 592-596.
[1]赵铁,殷婷婷,张英泽,陆进,李平,王国春,祖宁,阎小萍,张相林.基于代谢组学的强直性脊柱炎和痛风性关节炎湿热证共性特征研究[J].中医杂志,2013,54(07):592-596. DOI： 10.13288/j.11-2166/r.2013.07.015.

ZHAO Tie1, YIN Tingting2, ZHANG Yingze1, et al. Study on Common Features of Damp-Heat Syndrome in Rheumatism Based on Metabolomics[J]. Journal of Traditional Chinese Medicine2013, 54(7): 592-596. DOI： 10.13288/j.11-2166/r.2013.07.015.

摘要

目的探讨风湿性疾病湿热证的共性代谢物组特征。方法采用气相色谱-飞行时间质谱联用技术

对强直性脊柱炎（AS）湿热证患者30例、痛风性关节炎（GA）湿热证患者29例及健康志愿者44例的血清样本进行代谢组学研究

比较AS湿热证患者、GA湿热证患者相对于健康志愿者（正常组）血清中与湿热证相关的共性差异代谢物组。结果与正常组相比

α-羟基丁酸、磷酸和甘露糖在GA和AS湿热证组血清中均明显升高

而乙醇胺则明显下降。结论血清α-羟基丁酸、磷酸、甘露糖和乙醇胺可能为风湿性疾病湿热证的共性代谢物组特征。

Abstract

Objective To research the common metabolomic feature of rheumatism with damp-heat syndrome.Methods A metabolomic study of serum samples was conducted in 30ankylosing spondylitis（AS）patients with damp-heat syndrome

29 gouty arthritis（GA）patients with damp-heat syndrome and 44healthy volunteers by gas chromatography-time-of-flight mass spectrometry（GC-TOFMS）.The Common difference metabolomics associated with damp-heat syndrome in AS patients with damp-heat syndrome and GA patients with damp-heat syndrome were compared with the healthy volunteers.Results Comparing with the healthy volunteers

α-hydroxy acid

phosphoric acid and mannose was significantly increased but ethanolamine was significantly decreased in AS patients with damp-heat syndrome and GA patients with damp-heat syndrome.Conclusion The common metabolomic feature of rheumatism with damp-heat syndrome may beα-hydroxy acid

phosphoric acid

mannose and ethanolamine.

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ZHANG Yingze

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LI Ping

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YAN Xiaoping

Related Institution

Japan Friendship Hospital

Guang 'anmen Hospital，China Academy of Chinese Medical Sciences

Graduate School of Beijing University of Chinese Medicine

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