A Study of Medication Law in 592 Effective Cases of Chronic Hepatitis B with Damp-Heat Syndrome

ZHANG Lei1; ZHOU Xuezhong1; YU Jian1; WANG Yiguo2; ZHANG Qiming2

doi:10.13288/j.11-2166/r.2013.08.010

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A Study of Medication Law in 592 Effective Cases of Chronic Hepatitis B with Damp-Heat Syndrome

更新时间：2021-11-17

- A Study of Medication Law in 592 Effective Cases of Chronic Hepatitis B with Damp-Heat Syndrome
- Journal of Traditional Chinese Medicine Vol. 54, Issue 8, Pages: 668-672(2013)
- 作者机构：
  
  1. 北京交通大学计算机与信息技术学院
  2. 中国中医科学院中医临床基础医学研究所
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2013.08.010
  CLC： R259
- Published：2013
- 稿件说明：
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[1]张磊,周雪忠,于剑,王义国,张启明.592例慢性乙型病毒性肝炎湿热证有效病例用药规律研究[J].中医杂志,2013,54(08):668-672.

ZHANG Lei1, ZHOU Xuezhong1, YU Jian1, et al. A Study of Medication Law in 592 Effective Cases of Chronic Hepatitis B with Damp-Heat Syndrome[J]. Journal of Traditional Chinese Medicine2013, 54(8): 668-672.
[1]张磊,周雪忠,于剑,王义国,张启明.592例慢性乙型病毒性肝炎湿热证有效病例用药规律研究[J].中医杂志,2013,54(08):668-672. DOI： 10.13288/j.11-2166/r.2013.08.010.

ZHANG Lei1, ZHOU Xuezhong1, YU Jian1, et al. A Study of Medication Law in 592 Effective Cases of Chronic Hepatitis B with Damp-Heat Syndrome[J]. Journal of Traditional Chinese Medicine2013, 54(8): 668-672. DOI： 10.13288/j.11-2166/r.2013.08.010.

摘要

目的研究中医治疗慢性乙型病毒性肝炎（慢性乙肝）湿热证用药规律。方法筛选慢性乙肝湿热证有效病例592例

提取592个病例对应的中药处方

应用频数分析、方剂匹配、因子分析、复杂网络分析等多种方法对其用药规律进行分析。结果慢性乙肝湿热证使用频次最高的前5味药为茯苓、白术、叶下珠、猪苓、泽泻。共有208个处方经过方剂匹配后剩余药物个数≤3个

计算其在处方中的出现频数

频次大于3的方剂为茵陈五苓散（76）、四君子汤合四逆散合温胆汤（41）、龙胆泻肝汤（36）、加味逍遥散（7）、柴胡疏肝散（5）、茵陈蒿汤（5）、参苓白术散（4）、甘露消毒丹（3）、五味消毒饮合茵陈蒿汤（3）。有384个处方剩余药物个数>3个

多是自拟方

因子分析以特征根大于1作为选择公因子的标准

共获得公因子43个

得出了出现频次≥5的公因子对应的药物组合

这些处方组成网络图中边的权重分布幂函数指数值为1.8

以此作为α值

3作为层次数进行多层核心网络分析

得出3层网络图。结论慢性乙肝湿热证常用祛湿、疏肝、解毒、活血药物

最常用的3个方剂为茵陈五苓散、四君子汤合四逆散合温胆汤、龙胆泻肝汤

常用自拟方药物组合方式为祛湿+疏肝+解毒、益气+活血+祛湿

并常配合现代药理研究具有保肝降酶功效的中药。

Abstract

Objective To study the Chinese medication law of chronic hepatitis B with damp-heat syndrome.Methods Totally 592 effective cases of chronic hepatitis B with damp-heat syndrome were selected and the formulas were extracted.The medication law was analyzed with frequency analysis

formula match

factor analysis and complex network.Results The top 5 frequently used medicinals for chronic hepatitis B with damp-heat syndrome were Fuling （Poria）

Baizhu （Rhizoma Atractylodis Macrocephalae）

Yexiazhu （Phyllanthi Urinariae Herba）

Zhuling （Polyporus） and Zexie （Rhizoma Alismatis）.There were 208 formulas with less than or equal to 3 remained medicinals after formula match.The formulas which frequency over 3 were:Yinchen Wuling Powder （76）

Sijunzi Decoction-Sini Powder-Wendan Decoction （41）

Longdan Xiegan Decoction （36）

Jiawei Xiaoyao Powder （7）

Chaihu Shugan Powder （5）

Yinchenhao Decoction （5）

Shenling Baizhu Powder （4）

Ganlu Xiaodu Elixir （3） and Wuwei Xiaodu Beverage-Yinchenhao Decoction （3）.There were 384 formulas with more than 3 remained medicinals after formula match and most were self-formulated.The characteristic root over 1 was selected as the standard of common factor.A Total of 43 common factors and the medicinal combinations corresponding to the common factors （occurrence frequency≥5） were obtained.The power function index value of edge weight distribution in the network graph of formulas was 1.8.Taking 1.8 as the value of α and 3 as the number of layers

a 3-layer network diagram was got by multilayer core network analysis.Conclusion The commonly used medicinals for chronic hepatitis B with damp-heat syndrome are dampness-dispelling medicinal

liver-coursing medicinal

toxin-resolving medicinal and blood-quickening medicinal.The top 3 frequently used formulas for chronic hepatitis B with damp-heat syndrome are Yinchen Wuling Powder

Sijunzi Decoction-Sini Powder-Wendan Decoction and Longdan Xiegan Decoction.The combinations of commonly used self-formulated formulas are dampness-dispelling+liver-coursing+toxin-resolving and qi-supplementing+blood quickening+dampness-dispelling

often with hepatoprotective and anti-transaminase medicinals according to modern pharmacology.

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Related Institution

China Academy of Chinese Medical Sciences

Department of Hepatology，Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine/National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion

Graduate School of Tianjin University of Traditional Chinese Medicine

Guang 'anmen Hospital，China Academy of Chinese Medical Sciences

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