Objective To observe the therapeutic effect of Kidney-Supplementing Liver-Regulating Formula （KSLRF） for elderly osteoporosis.Methods Eighty cases of osteoporosis （age≥75 years） were randomized into the treatment group and control group

with 40 in each.The treatment group was given decoction of KSLRF orally

one dose daily.The control group was given Alendronate Sodium Tablets orally

70 mg each time

once weekly.The treatment lasted for 4 weeks.The therapeutic effect

syndrome efficacy and pain efficacy was observed.The syndrome scores and pain scores were evaluated.ResultsThe total effective rate

syndrome efficacy and pain efficacy was 87.50%

93.75% and 71.88% in the treatment group respectively and 83.87%

83.87%and 74.19% in the control group

with a significant difference between groups in the syndrome efficacy （P<0.01）.The pain scores and syndrome scores were significantly decreased in both groups after 1

2

3 or 4 weeks of treatment （P<0.05）.The pain scores were decreased with the duration of treatment

especially in the 4th week of treatment （P<0.05）.After 2 or 3 weeks of treatment

the pain scores and syndrome scores in the treatment group were significantly lower than those in the control group at the same time point （P<0.05）.Conclusion KSLRF is effective for elderly osteoporosis and it can obviously relieve the pain and TCM symptoms.