Objective To study the effects of Blood Increasing Pill （BIP） on the liver

spleen

bone marrow cells （BMC） and peripheral blood lymphocytes （PBL） in mice chronically exposed to low-dose trichlorfon aqueous solution.Methods Totally 150 mice were randomized into the blank group （40 days of gavage with saline）

No.1 model group （20 days of gavage with trichlorfon+20 days of gavage with saline）

treatment group （20 days of gavage with trichlorfon+20 days of gavage with BIP）

No.2 model group （20 days of gavage with saline+20 days of gavage with trichlorfon） and prevention group （20 days of gavage with BIP+20 days of gavage with trichlorfon）.The dose of trichlorfon and BIP was 2 mg/kg and 2.5 g/kg respectively administered once daily.The optical density （OD） values of hydroxyl radical

superoxide anion activity and ornithine decarboxylase （ODC） in the liver cells and spleen cells were detected and the micronucleus rates in PBL and BMC were calculated.Results Comparing with the blank group

the OD values of hydroxyl radical and superoxide anion activity in the liver cells and the micronucleus rates in PBL in two model groups were significantly increased （P<0.05）

but the OD values of ODC were significantly decreased （P<0.05）.Both the differences between the treatment group and No.1 model group and between the prevention group and No.2 model group were statistically significant in the OD values of hydroxyl radical

superoxide anion activity and ODC in the liver cells and the micronucleus rate in PBL （P<0.05）.There was no significant difference between groups in the OD values of hydroxyl radical

superoxide anion activity and ODC in the spleen cells and the micronucleus rate in BMC （P>0.05）.Conclusion BIP can effectively prevent and relieve the hepatocytes oxidative damage and reduce the micronucleus rate in PBL in mice exposed to low-dose trichlorfon.