Objective To observe the therapeutic effect of Supplemented Suanzaoren Decoction（Supplemented Spiny Jujube Decoction）for insomnia with liver-blood deficiency pattern and its effect on monoamine neurotransmitters.Methods Totally 120insomnia patients with liver-blood deficiency pattern were randomized into the TCM treatment group and western medicine（WM）control group

with 60in each.Sixty normal sleepers were chosen as the normal control group.The TCM treatment group was given Supplemented Suanzaoren Decoction granules one dosage daily and once with a half dose in the morning and evening respectively.The WM control group was given 1mg Estazolam Tablets 30min before bedtime orally.The treatment lasted for 2weeks.The normal control group was not given any special treatment.The insomnia patients were asked to fill the Pittsburgh Sleep Quality Index（PSQI）and self-rating scale of sleep（SRSS）on the admission day and after 2-week treatment.The levels of 5-hydroxytryptamine（5-HT）

5-hydroxy indole acetic acid（5-HIAA）andβ-endorphin（β-EP）were detected before and after treatment in the TCM treatment group and WM control group and when enrolled in the normal control group.The therapeutic effect was observed as well.Results The SRSS and PSQI scores were significantly improved in the TCM treatment group and WM control group after treatment（P<0.01）

especially in the TCM treatment group（P<0.05）.Comparing with the normal control group

the levels of 5-HT andβ-EP were significantly lower（P<0.01）but the 5-HIAA levels were significantly higher（P<0.01）in the insomnia patients with liver-blood deficiency pattern before treatment.After treatment

the levels of 5-HT andβ-EP were significantly increased in the TCM treatment group（P<0.01）and WM control group（P<0.05or P<0.01）

but the 5-HIAA levels were significantly decreased in the TCM treatment group（P<0.01）and WM control group（P<0.05）

especially in the TCM treatment group（P<0.05or P<0.01）.Comparing with the normal control group

the difference in 5-HT level was not statistically significant（P>0.05）

but theβ-EP level was significantly decreased（P<0.05）and 5-HIAA level was significantly increased（P<0.05）in the TCM treatment group after treatment.Comparing with the normal control group

the levels of 5-HT andβ-EP were significantly decreased（P<0.01）and 5-HIAA level was significantly increased（P<0.01）in the WM control group after treatment.The total effective rate in the TCM treatment group was 86.67%

which was superior to 75.00% in the WM control group（P<0.05）.Conclusion The monoamine neurotransmitters in insomnia patients with liver-blood deficiency pattern are disorder.Supplemented Suanzaoren Decoction can improve insomnia and balance neurotransmitters.