Objective To study the effects of Danshen Injection on the left ventricular remodeling（LVF）and cardiac function（CF）in acute myocardial infarction（AMI）rabbits.Methods The AMI models were established by ligation of anterior descending branch of the left coronary artery in rabbits.Thirty-two successfully modeling rabbits were randomized into the model group and Danshen Injection group

with 16in each.Another 16rabbits without ligation were threaded only and chosen as the sham operation group.The Danshen Injection group was gavaged with 0.5ml/100g Danshen Injection once daily for three weeks.The sham operation group and model group were given the conventional breeding.The general condition

bodysurface electrocardiogram（BS-ECG）

left ventricular end-systolic pressure（LVESP）

left ventricular end-diastolic pressure（LVEDP）

maximum rate of change in left ventricular pressure（dp/dtmax）

cardiac output（CO）

heart weight（HW）

ventricular weight index（VWI）and left-ventricular cavity diameter（D）were observed 1week and 3weeks after operation.Results The appetite

activities and response were decreased in model rabbits and the ECG showed large pathological Q waves.The food intakes of rabbits were recovered and only 2pathological Q waves were left in the Danshen Injection group.Comparing with the sham operation group

the LVESP

dp/dtmax and CO was significantly decreased but the LVEDP was significantly increased in the model group 3weeks after operation（P<0.05or P<0.01）.Comparing with the model group

the LVESP

dp/dtmax and CO was significantly increased but the LVEDP was significantly decreased in the Danshen Injection group（P<0.05or P<0.01）.Comparing with the sham operation group

the HW

VWI and D was significantly increased in the model group 3weeks after operation（P<0.05or P<0.01）.Comparing with the model group

the HW

VWI and D was significantly decreased in the Danshen Injection group（P<0.05or P<0.01）.Conclusion Danshen Injection can improve the LVR parameters

increase CO and improve CF in AMI rabbits.