Effect of Xiaoyao Pill on the ALK5/Smads Pathway of Granulosa Cells in Wall of Ovarian Follicle

LIANG Ying1; ZHAO Shengnan1; CHANG Xiufeng2; DU Huilan1

doi:10.13288/j.11-2166/r.2013.09.027

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Effect of Xiaoyao Pill on the ALK5/Smads Pathway of Granulosa Cells in Wall of Ovarian Follicle

更新时间：2021-11-17

- Effect of Xiaoyao Pill on the ALK5/Smads Pathway of Granulosa Cells in Wall of Ovarian Follicle
- Journal of Traditional Chinese Medicine Vol. 54, Issue 9, Pages: 754-757(2013)
- 作者机构：
  
  1. 河北医科大学中西医结合学院
  2. 白求恩国际和平医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2013.09.027
  CLC： R737.31
- Published：2013
- 稿件说明：
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[1]梁莹,赵胜男,常秀峰,杜惠兰.逍遥丸对人卵巢壁颗粒细胞ALK5/Smads通路的影响[J].中医杂志,2013,54(09):754-757.

LIANG Ying1, ZHAO Shengnan1, CHANG Xiufeng2, et al. Effect of Xiaoyao Pill on the ALK5/Smads Pathway of Granulosa Cells in Wall of Ovarian Follicle[J]. Journal of Traditional Chinese Medicine2013, 54(9): 754-757.
[1]梁莹,赵胜男,常秀峰,杜惠兰.逍遥丸对人卵巢壁颗粒细胞ALK5/Smads通路的影响[J].中医杂志,2013,54(09):754-757. DOI： 10.13288/j.11-2166/r.2013.09.027.

LIANG Ying1, ZHAO Shengnan1, CHANG Xiufeng2, et al. Effect of Xiaoyao Pill on the ALK5/Smads Pathway of Granulosa Cells in Wall of Ovarian Follicle[J]. Journal of Traditional Chinese Medicine2013, 54(9): 754-757. DOI： 10.13288/j.11-2166/r.2013.09.027.

摘要

目的研究逍遥丸治疗不孕症的可能作用机制。方法 60例接受体外受精-胚胎移植（IVF-ET）治疗的不孕症患者中肝郁证者21例（治疗组）

其余39例患者为对照组。对照组采用西医常规方案促排卵

治疗组在对照组的基础上口服逍遥丸

每次20丸

早晚分服。测定两组患者成熟卵泡壁颗粒细胞激活素受体激酶5（ALK5）、Smad2、Smad3和Smad 4mRNA和蛋白的表达。结果治疗组颗粒细胞ALK5和Smad2 mRNA及蛋白的表达显著高于对照组（P<0.05）;Smad3、Smad4 mRNA和蛋白的表达两组比较差异无统计学意义（P>0.05）。结论逍遥丸治疗不孕症的机制可能与上调壁颗粒细胞受体ALK5和Smad2 mRNA及蛋白

调节ALK5/Smads信号通路而达到促进卵泡发育目的

调节卵巢功能。

Abstract

Objective To research the possible mechanism of Xiaoyao Pill（Free Wanderer Pill）for infertility.Methods Sixty cases of infertility undergoing in vitro fertilization-embryo transfer（IVF-ET）were grouped into the treatment group（21 cases

with liver depression pattern）and control group（39cases）.Both groups were induced ovulation with routine western medicine and the treatment group was added with Xiaoyao Pill orally

20pills once

in the morning and evening.The expressions of activin receptor-like kinase 5（ALK5）

Smad2

Smad3and Smad4proteins

ALK5mRNA

Smad2mRNA

Smad3 mRNA and Smad4mRNA of granulosa cells in wall of ovarian follicle in both groups were detected.Results The expressions of ALK5protein

Smad2protein

ALK5mRNA and Smad2mRNA were significantly higher than those in the control group（P<0.05）.There was no significant difference between groups in the expressions of Smad3protein

Smad4protein

Smad3 mRNA and Smad4mRNA（P>0.05）.Conclusion The possible mechanism of Xiaoyao Pill for infertility is up-regulating the expressions of ALK5protein

Smad2protein

ALK5mRNA and Smad2mRNA and regulating ALK5/Smads signaling pathway to promote the follicular development and regulate ovarian function.

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Related Institution

Xiyuan Hospital，China Academy of Chinese Medical Sciences

Japan Friendship Hospital

Collaborative Innovation Center for Reproductive Diseases of Integrated Traditional Chinese and Western Medicine in Hebei Province

School of Integrated Traditional Chinese and Western Medicine，Hebei University of Chinese Medicine

Traditional Chinese and Western Medicine Integration Hospital of Fengtai District

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