Objective To evaluate the therapeutic effect of Supplemented Shegan Mahuang Decoction （Belamcanda and Ephedra Decoction

SSMD） on refractory asthma. Methods Sixty five cases of refractory asthma were randomized into treatment group of 33 cases and control group of 32 cases. Both groups were given the basic treatment such as regular inhalation of Seretide and Ventolin and oral administration of Theophylline Sustained-Release Tablets. In asthma remission

the dose of β2-agonists and theophylline was gradually reduced until withdrawal. The treatment group was given SSMD one dose daily in addition. Both groups were treated for 12 weeks. The asthma control test （ACT） scores

forced expiratory volume in one second （FEV1） and peak expiratory flow （PEF） were observed before and after 4-week

8-week and 12-week treatment. The therapeutic effect was evaluated. Results The total effective rate of the treatment group and control group was 78.8% and 43.8% respectively

with significant difference between groups （P<0.05）. The ACT scores

FEV1 and PEF were significantly improved in both groups in the 4th

8th and 12th week of treatment （P<0.05）

especially in the treatment group （P<0.05）. Conclusion SSMD is effective for refractory asthma and it can effectively relieve the clinical symptoms and improve the lung function.