Objective To study the effect of Fuzheng Tixie Souluo Formula （Right-Supporting

Evil-Dispelling and Network Vessels-Tracking Formula

FTSF） on the lung function in rats with pulmonary fibrosis. Methods Totally 128 SD rats were randomized into sham operation group

model group

FTSF group and Prednisone group

with 32 in each. The pulmonary fibrosis models were established with intratracheal injection of bleomycin 0.25 ml/100 g. The sham operation group was injected with equal volume of normal saline. The FTSF group and Prednisone group was given 0.74g/（kg·d） FTSF and 5mg/（kg·d） Prednisone respectively

and the sham operation group and model group were given equal volume of normal saline 24 hours after modeling. The lung pathology results

inspiratory resistance （Ri）

lung compliance （Cl）

forced vital capacity （FVC）

forced expiratory volume in 0.2 second （FEV0.2） and forced expiratory flow between 25% and 75% of FVC （FEF25-75%） were observed on the 7th

14th

28th and 45th day after administration. Results There were varying degrees of inflammation in pulmonary interstitial on the 7th day

significantly increased collagen fibers on the 14th day

increased pulmonary fibrosis area on the 28th day and honeycomb lung on the 45th day in the model group. Comparing with the model group

the degrees of alveolitis and fibrosis in the FTSF group and Prednisone group were slighter. Comparing with the model group

the Cl and FVC was significantly increased on the 14th day in FTSF group （P<0.01）. There were significant differences between the model group and FTSF group in Ri

Cl

FVC

FEV0.2 and FEF25-75% on the 28th day （P<0.01） and Ri

Cl

FEV0.2 and FEF25-75% on the 45th day （P<0.05 or P<0.01）. Comparing with Prednisone group

Ri was significantly decrease （P<0.01） and CI was significantly increased in FTSF group （P<0.01）. Conclusion FTSF can improve the lung function in rats with pulmonary fibrosis

especially when early intervention and maintaining a certain course of treatment.