Objective To observe the effect of Tongxinluo Superfine Powder （TSP

superfine powder to free the heart vessels） on microvessels and blood perfusion in cerebral ischemia rats. Methods Totally 48 healthy SPF SD rats were randomized into sham operation group

model group

TSP high-dose group （1.6 g/kg·d）

TSP middle-dose group （0.8 g/kg·d）

TSP low-dose group （0.4 g/kg·d） and nimodipine group （10 mg/kg·d）

with 8 in each. The focal cerebral ischemia models were established with craniotomy ligation of one side of the middle cerebral artery. The rat meninges in the sham operation group were picked open without vascular ligation. Each treatment group was given intragastric administration after waking and the sham operation group and model group were given the same volume of normal saline. The morphology

diameters and blood perfusion of cerebral microvessels were observed with laser scanning confocal microscopy on the 14th day of administration. Results Comparing with the model group

the cerebral cortex microvessels in each treatment group showed a tortuous and irregular shape and the cerebral cortex microvessels in the TSP high-dose group showed obviously irregular shape

numerous microvascular branch and close connection between microvessels. The diameter of 40% microvascular of ischemic side of the rats in the model group was 5 to 6 μm. The diameter of 41% microvascular of ischemic side of the rats in the TSP high-dose group was 2 to 3 μm. The diameter of 40% microvascular of ischemic side of the rats in the TSP middle-dose group was 3 to 4 μm. The diameter of 40% microvascular of ischemic side of the rats in the TSP low-dose group was 4 to 5 μm. Comparing with the model group

the blood perfusion in the TSP high-dose group

TSP middle-dose group and nimodipine group was significantly increased （P<0.01 or P<0.05）. Conclusion TSP can promote angiogenesis in cerebral cortex after focal cerebral ischemia and increase the blood perfusion.