Effect of Sulfotanshinone Sodium Injection on the Platelet Function in Patients with Coronary Heart Disease

YANG Juan1; DONG Jiangchuan2; LI Dazhu3; WANG Boyuan3; LIN Jing3; ZHANG Pei3

doi:10.13288/j.11-2166/r.2013.15.014

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Effect of Sulfotanshinone Sodium Injection on the Platelet Function in Patients with Coronary Heart Disease

更新时间：2021-11-17

- Effect of Sulfotanshinone Sodium Injection on the Platelet Function in Patients with Coronary Heart Disease
- Journal of Traditional Chinese Medicine Vol. 54, Issue 15, Pages: 1294-1296(2013)
- 作者机构：
  
  1. 重庆医科大学附属第一医院中西医结合科
  2. 重庆医科大学中医药学院临床教研室
  3. 华中科技大学同济医学院附属协和医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2013.15.014
  CLC： R259
- Published：2013
- 稿件说明：
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[1]杨涓,董江川,李大主,王博远,林静,张沛.丹参酮Ⅱ_A磺酸钠对冠心病患者血小板功能的影响[J].中医杂志,2013,54(15):1294-1296.

YANG Juan1, DONG Jiangchuan2, LI Dazhu3, et al. Effect of Sulfotanshinone Sodium Injection on the Platelet Function in Patients with Coronary Heart Disease[J]. Journal of Traditional Chinese Medicine2013, 54(15): 1294-1296.
[1]杨涓,董江川,李大主,王博远,林静,张沛.丹参酮Ⅱ_A磺酸钠对冠心病患者血小板功能的影响[J].中医杂志,2013,54(15):1294-1296. DOI： 10.13288/j.11-2166/r.2013.15.014.

YANG Juan1, DONG Jiangchuan2, LI Dazhu3, et al. Effect of Sulfotanshinone Sodium Injection on the Platelet Function in Patients with Coronary Heart Disease[J]. Journal of Traditional Chinese Medicine2013, 54(15): 1294-1296. DOI： 10.13288/j.11-2166/r.2013.15.014.

摘要

目的探讨丹参酮ⅡA磺酸钠治疗冠心病的作用机制。方法 89例冠心病患者随机分为治疗组45例和对照组44例。对照组采用阿司匹林、硝酸酯类、他汀类降脂药等常规治疗

治疗组在常规治疗基础上加用丹参酮ⅡA磺酸钠注射液

两组均连续用药7天。于治疗开始前1天及结束次日检测两组血液流变学、纤维蛋白原（Fg）、血小板聚集率（PAG）与血小板膜糖蛋白CD62p、CD63、CD42b及PAC-1水平。结果两组患者治疗后高切全血黏度、低切全血黏度、血浆比黏度、Fg、PAG较治疗前均明显降低

并且治疗组较对照组降低更明显（P<0.05或P<0.01）;两组患者治疗后CD62p、CD63、CD42b及PAC-1表达较治疗前均有明显改善（P<0.01）

治疗组CD62p、CD63及PAC-1的表达与对照组比较下降更明显（P<0.05或P<0.01）。结论丹参酮ⅡA磺酸钠改善冠心病患者血液流变学

降低血浆Fg水平

抑制血小板聚集

抗血小板活化可能是其治疗冠心病的途径之一。表2两组患者治疗前后CD62p、CD63、PAC-1、CD42b水平比较（%

珚x±s）组别时间例数CD62pPAC-1CD63CD42b对照组治疗前445.91±1.166.58±0.786.27±1.4989.32±15.54治疗后444.06±0.87*5.13±0.86*4.04±1.63*95.28±16.39*治疗组治疗前455.79±1.326.42±0.916.46±1.7290.11±13.47治疗后453.73±1.08*△△4.85±1.14*△3.91±1.58*△97.89±14.76*注:与本组治疗前比较

*P<0.01;与对照组治疗后比较

△P<0.05

△△P<0.013.3不良反应是其治疗CHD的机制之一

是临床确切有效的

Abstract

Objective To research the effect and mechanism of sulfotanshinone sodium （STS） Injection on patients with coronary heart disease （CHD）. Methods Totally 89 CHD patients were randomized into treatment group of 45 cases and control group of 44 cases. The control group was given conventional treatment of aspirin

nitrates and lipid-lowering statins. The treatment group was added with STS injection. Both groups were administered for 7 continuous days. The blood rheology

fibrinogen （Fg）

platelet aggregation （PAG） and platelet membrane glycoprotein CD62p

CD63

CD42b and PAC-1 were detected one day before treatment and one day after treatment. Results The high-shear whole blood viscosity

low-shear whole blood viscosity

plasma viscosity

Fg and PAG were significantly decreased in both groups after treatment

especially in the treatment group （P<0.05 or P<0.01）. The expressions of CD62p

CD63

CD42b and PAC-1 were significantly improved in both groups after treatment （P<0.01）

especially the expressions of CD62p

CD63 and PAC-1 in the treatment group （P<0.05 or P<0.01）. Conclusion STS can improve blood rheology

decrease plasma Fg level and inhibit platelet aggregation in CHD patients and anti-platelet activation may be one way to treat CHD.

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